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Visar resultat 1 - 5 av 22 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Imaging neurochemical changes associated with Parkinson´s disease and L-DOPA-induced dyskinesia using mass spectrometry

    Författare :Elva Fridjonsdottir; Per E. Andrén; Miles Trupp; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mass spectrometry imaging; MALDI; Parkinson´s disease; L-DOPA-induced dyskinesia;

    Sammanfattning : Parkinson’s disease (PD), caused by a loss of midbrain dopamine neurons, is the second most common neurodegenerative disease worldwide after Alzheimer’s disease. The primary treatment choice for PD is L-DOPA, the precursor for dopamine, which only affects symptoms and does not inhibit disease progression. LÄS MER

  3. 2. Parkinson’s disease and depression : clinical and neurobiological studies

    Författare :Sven E Pålhagen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Parkinson´s disease. Major depressive disorder; SSRI; rCBF; CSF-biomarker;

    Sammanfattning : Parkinson´s disease (PD) is a progressive degenerative movement disorder. PD patients also suffer from several non-motor symptoms including autonomic disturbances, cognitive decline and neuropsychiatric conditions. LÄS MER

  4. 3. Paving the way : the second generation of e-patients, their experiences, actions and driving forces

    Författare :Therese Scott Duncan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :E-patients;

    Sammanfattning : Background: E-patients are described as patients and informal caregivers who are empowered, equipped, enabled and engaged, and use digital solutions for their self-care and in healthcare contexts. Self-care can be understood as health related activities and behaviors regarding life styles and environmental aspects. LÄS MER

  5. 4. Development and Characterisation of a Rat Model of Parkinson's Disease

    Författare :Matilde Negrini; Beteendevetenskapligt laboratorium; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson s disease PD ; behavior; gene therapy; rat model; dopamine; alpha-synuclein; AAV Adeno-Associated virus ; PFFs;

    Sammanfattning : Preclinical rodent models of Parkinson’s Disease (PD) based on alpha-synuclein (αSyn) present some of the pathological hallmarks of the human condition, such as the progressive loss of dopaminergic neurons in the substantia nigra (SN) and the development of behavioural deficits. However, numerous reports on these models highlighted the variable outcomes that might originate from them if not validated properly. LÄS MER

  7. 5. Deuterium-L-DOPA : a novel means to improve treatment of Parkinson's disease

    Författare :Torun Malmlöf; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : L-DOPA, the precursor of dopamine, is administered to restore dopamine deficiency in Parkinson´s disease (PD) patients. L-DOPA initially provides a sustained symptomatic relief with superior efficacy as compared to other treatments, while long term treatment is complicated by the gradual emergence of troublesome motor complications i.e. LÄS MER