Sökning: "Dkk1"

Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet Dkk1.

  1. 1. Pancreatic Endocrine Tumourigenesis : Genes of potential importance

    Författare :Térèse A. Johansson; Barbro Eriksson; Britt Skogseid; Gunnar Westin; Martin Bäckdahl; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pancreatic endocrine tumour; Multiple endocrine neoplasia type 1; Tumourigenesis; Notch signalling; Notch1; Hes1; Neurog3; Neurod1; Men1; Ascl1; Pou3f4; Pdx1; Rpl10; Dlk1; Dkk1; Tph1; menin; Tumour biology; Tumörbiologi;

    Sammanfattning : Understanding signalling pathways that control pancreatic endocrine tumour (PET) development and proliferation may reveal novel targets for therapeutic intervention. The pathogenesis for sporadic and hereditary PETs, apart from mutations of the MEN1 and VHL tumour suppressor genes, is still elusive. LÄS MER

  3. 2. The Wnt pathway in ventral midbrain dopaminergic differentiation

    Författare :Diogo Ribeiro; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Parkinson’s disease (PD) is a debilitating neurodegenerative disease in which dopaminergic (DA) neurons in the substantia nigra are lost. Current treatments such as administration of levodopa (L-DOPA) are initially effective but the disease eventually progresses, highlighting the need for a treatment that restores and maintains the otherwise lost functions. LÄS MER

  4. 3. Alterations in proliferation and differentiation of neural stem cells induced by adverse neurodevelopmental factors

    Författare :Raj Kumar Bose; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Predisposition to diseases can be acquired during early stages of development and resolve into an actual disorder later in life. Early life programming defines the association between challenges during pregnancy that result in altered fetal growth, and developmental and adult disorders. LÄS MER

  5. 4. Identification of novel tumor biomarkers for sensitivity to radio- and chemotherapy of lung cancer based on genomic analyses

    Författare :Hogir Salim; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Lung cancer (LC) is one of the most common human cancers and the leading cause of cancer-related deaths worldwide. Treatment of LC is by surgery if the tumor is resectable, otherwise chemo- and/or radiotherapy (CT/RT) is given. LÄS MER

  7. 5. Wnt/β-Catenin Signalling in Parathyroid Tumours

    Författare :Peyman Björklund; Gunnar Westin; Göran Åkerström; Tommy Andersson; Uppsala universitet; []
    Nyckelord :Surgery; Hyperparathyroidism; β-catenin; Mutation; Human parathyroid cell line; LRP5; Alternative splicing; Kirurgi;

    Sammanfattning : Primary hyperparathyroidism (pHPT) due to parathyroid tumours with hypersecretion of parathyroid hormone and hypercalcaemia is a common disease with incompletely understood etiology affecting more than 1 % of the population, primarily postmenopausal women. In secondary hyperparathyroidism (sHPT), parathyroid tumours develop in response to calcium and vitamin D deficiency generally in patients with uraemia. LÄS MER