Sökning: "Ascl1"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet Ascl1.

  1. 1. Pancreatic Endocrine Tumourigenesis : Genes of potential importance

    Författare :Térèse A. Johansson; Barbro Eriksson; Britt Skogseid; Gunnar Westin; Martin Bäckdahl; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pancreatic endocrine tumour; Multiple endocrine neoplasia type 1; Tumourigenesis; Notch signalling; Notch1; Hes1; Neurog3; Neurod1; Men1; Ascl1; Pou3f4; Pdx1; Rpl10; Dlk1; Dkk1; Tph1; menin; Tumour biology; Tumörbiologi;

    Sammanfattning : Understanding signalling pathways that control pancreatic endocrine tumour (PET) development and proliferation may reveal novel targets for therapeutic intervention. The pathogenesis for sporadic and hereditary PETs, apart from mutations of the MEN1 and VHL tumour suppressor genes, is still elusive. LÄS MER

  3. 2. Investigation of small-cell lung cancer epidemiology in Sweden and analysis of clinical and tumor specific prognostic biomarkers

    Författare :Salomon Tendler; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Small-cell lung cancer (SCLC) accounts for approximately 13% of all newly diagnosed lung cancer (LC) cases. This disease is correlated with heavy smoking. It is characterized by a rapid doubling time combined with a propensity to metastasize quickly and by neuroendocrine differentiation. LÄS MER

  4. 3. Exploration of large molecular datasets using global gene networks : computational methods and tools

    Författare :Ashwini Priya Jeggari; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Defining gene expression profiles and mapping complex interactions between molecular regulators and proteins is a key for understanding biological processes and the functional properties of cells, which is therefore, the focus on numerous experimental studies. Small-scale biochemical analyses deliver high-quality data, but lack coverage, whereas high throughput sequencing reveals thousands of interactions which can be error-prone and require proper computational methods to discover true relations. LÄS MER

  5. 4. Generation of induced neurons via direct conversion in vivo and in vitro

    Författare :Olof Torper; Neurobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cellular reprogramming; cell replacement therapies; induced dopaminergic neurons; in vivo reprogramming; Lentiviral vectors; AAV vectors;

    Sammanfattning : Cellular reprogramming is when one cell is changed into another. This involves structural modifications on the DNA of a cell resulting in a transcriptional change. This occurs naturally during development when early pluripotent cells gradually differentiate into more specialized cells that finally result in a complete organism. LÄS MER

  7. 5. Specification of enteric neuron subtypes in the developing gut

    Författare :Viktoria Knoflach; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The enteric nervous system (ENS) is the biggest subdivision of the peripheral nervous system and harbors more neurons than the spinal cord. Its intricate network of ganglia is spanning the entire length of the gastrointestinal wall from where it controls peristalsis, secretion and blood flow. LÄS MER