Sökning: "Cell phototoxicity"
Hittade 5 avhandlingar innehållade orden Cell phototoxicity.
1. Illumination in single cell optical microscopy studies - friend and foe
Sammanfattning : This thesis focuses on how to use light as a biological stress factor in optical microscopy experiments and simultaneously use the illumination to image the spatial and temporal protein dynamics in single yeast cells. The stress responses to environmental changes other than light have been extensively investigated in budding yeast, Saccharomyces cerevisiae, often using techniques based on population averages. LÄS MER
2. Modern Computational Physical Chemistry : An Introduction to Biomolecular Radiation Damage and Phototoxicity
Sammanfattning : The realm of molecular physical chemistry ranges from the structure of matter and the fundamental atomic and molecular interactions to the macroscopic properties and processes arising from the average microscopic behaviour.Herein, the conventional electrodic problem is recast into the simpler molecular problem of finding the electrochemical, real chemical, and chemical potentials of the species involved in redox half-reactions. LÄS MER
3. Exploring nanosystems for biomedical applications focusing on photodynamic therapy and drug delivery
Sammanfattning : The increasing incidences of cancer and related deaths call for the development of new and improved treatment modalities. Photodynamic therapy (PDT) today is an alternative to conventional treatments, but has limitations. This thesis explores different nanosystems with aim to improve PDT focusing on spectroscopic and ex vivo studies. LÄS MER
4. Computational studies of photodynamic drugs, phototoxic reactions and drug design
Sammanfattning : The most important criterion when designing new drugs or improving old ones in order to prevent side effects or at least diminish them is drug safety. Treatment of all diseases generally needs use of either topical application or systemic medications (transported in the blood) during a certain period of time. LÄS MER
5. Erythropoietic protoporphyria clinical and epidemiological aspects
Sammanfattning : Erythropoietic protoporphyria, EPP, is an inherited disease in which the main clinical manifestations are painful cutaneous sensitivity to intense light and liver disease which in some requires liver transplantation for survival. This thesis originated in questions and perceived limitations in understanding that accompanied the management of the patient in Study I. LÄS MER