Sökning: "lead II cleavage"
Visar resultat 1 - 5 av 16 avhandlingar innehållade orden lead II cleavage.
1. Lead(II) as a Tool for Probing RNA Structure in vivo
Sammanfattning : Chemical modification and limited enzymatic hydrolysis are powerful methods to obtain detailed information on the structure and dynamics of RNAs in solution. In the work presented here I have taken advantage of the properties of the divalent metal ion lead(II) to establish it as a new probe for investigating the structure of RNA in vivo. LÄS MER
2. Development of chemical biology tools for metabolomics analysis : Phase II modifications as a link between host and microbiota co-metabolism
Sammanfattning : Biomarker discovery is an extremely important field for early disease detection. New selective molecular markers are in high demand, as an earlier disease detection can lead to improved patient care. LÄS MER
3. Targeting bacterial infections by using immunomodulatory host defence peptides and proteins
Sammanfattning : Bacterial infections and sepsis are amongst the leading causes of death worldwide. Sepsis is caused by an uncontrolled systemic host response towards an invading pathogen. Due to the engagement of various systems including cellmediated responses, the coagulation and complement cascades, treatment of sepsis remains challenging. LÄS MER
4. On the mechanism and consequences of light-induced D₁ protein degradation in higher plants
Sammanfattning : The basic source of energy for the whole biosphere is sunlight which is converted tochemical energy by the process of photosynthesis in a wide variety of organisms rangingfrom prokaryotic bacteria to eukaryotic higher plants. It is therefore surprising thatphotosynthetic activity can be reduced when plants are exposed to excessive light,especially under adverse environmental conditions. LÄS MER
5. HOST DEFENSE PEPTIDES OF THE COAGULATION SYSTEM AND THEIR THERAPEUTIC POTENTIAL
Sammanfattning : Prevention and control of infectious diseases is seriously hampered by an increasing prevalence of bacteria that are resistant towards conventional antibiotics. Resistant bacteria are often the root cause of infections that trigger the complex clinical syndrome called sepsis, which is a concern for high morbidity and mortality. LÄS MER