Sökning: "FLIM"

Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet FLIM.

1. 1. Exploring nanosystems for biomedical applications focusing on photodynamic therapy and drug delivery

   Författare :Vladimir Kirejev; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Photodynamic therapy; PDT enhancement; Nitric oxide; NO-based PDT; Targeted drug delivery; Galectin-3; mTHPP; Cyclodextrin; CD-mTHPP conjugate; PpIX AuNP combination; Two-photon microscopy; FLIM; Cell phototoxicity; Ex vivo skin;

   Sammanfattning : The increasing incidences of cancer and related deaths call for the development of new and improved treatment modalities. Photodynamic therapy (PDT) today is an alternative to conventional treatments, but has limitations. This thesis explores different nanosystems with aim to improve PDT focusing on spectroscopic and ex vivo studies. LÄS MER

3. 2. Multiphoton Microscopy Targeting Tissue Development. Towards the real-time imaging of epidermal differentiation

   Författare :Monika Malak; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; multiphoton microscopy; fluorescence lifetime imaging; epidermal differentiation; reconstructed human epidermis; organ-on-a-chip; intrinsic fluorescence;

   Sammanfattning : The development of novel organ-on-a-chip models calls for methodologies, which will allow the study of tissue development and pharmacological outcome in real-time. Multiphoton microscopy (MPM) has been proposed as a suitable technique for noninvasive imaging of live specimens, utilizing intrinsic tissue fluorescence. LÄS MER

4. 3. Laser Scanning Multiphoton Microscopy – Focusing on Fluorescence Correlation Spectroscopy and Fluorescence Lifetime Imaging for Biomedical Applications

   Författare :Jeemol James; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Laser scanning multiphoton microscopy; intrinsic cellular fluorophores.; fluorescence correlation spectroscopy; fluorescence lifetime imaging; melanoma metastasis;

   Sammanfattning : Laser scanning multiphoton microscopy (MPM) is considered as a non-invasive technology for three-dimensional imaging of complex biological tissues. The quantitative potential of the MPM is not investigated as much as qualitative imaging. LÄS MER

5. 4. Microbial ecology and virulence gene studies of the insect pathogen Bacillus thuringiensis

   Författare :Katarina Eskils; Malte Hermansson; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mikrobiologi; Microbiology;

   Sammanfattning : Bacillus thuringiensis (Bt) is a spore-forming bacterium used as a bio-pesticide due to its insect toxicity. Bt was used as a model organism in a risk evaluation project. Prevalence, survival and spreading, as well as genome stability, putative virulence genes, and gene transfer were examined. Field release of a marked Bt subsp. LÄS MER

7. 5. Methods for performance characterization of artificial molecular motors

   Författare :Ivan Unksov; NanoLund: Centre for Nanoscience; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

   Sammanfattning : The overall aim of this thesis work is to characterize artificial biomolecular motors, specifically the Lawnmower, a motor based on the burn bridges mechanism, and the Tumbleweed, a protein motor that employs ligand specific DNA-proteins binding to step along DNA. An overview of their operational principles is given, and initial results of our studies are presented, along with a review of currently available methods to characterize artificial molecular motors. LÄS MER