Sökning: "Anticancer drugs"

Visar resultat 16 - 20 av 86 avhandlingar innehållade orden Anticancer drugs.

  1. 16. The role of autophagy in anticancer therapy

    Författare :Matheus Dyczynski; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Autophagy is a fundamental catabolic process, which is utilized by nearly every cell and tissue type upon stress exposure and has been shown to contribute to resistance to chemotherapy in a variety of cancers. The subject of this thesis is to shed light on the role of autophagy in chemotherapy and to investigate novel regulators of autophagy. LÄS MER

  3. 17. On the role of different signal transduction pathways in induction of apoptosis by anticancer drugs

    Författare :Maria Berndtsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Anticancer drug treatment gives rise to complex cellular responses in tumor cells. An improved understanding of the mechanisms underlying these responses is important in order to improve treatment. It is also of importance to investigate novel mechanisms of drug action that could potentially represent new concepts for treatment. LÄS MER

  4. 18. Feasibility of the fluorometric microculture cytotoxicity assay (FMCA) in the preclinical evaluation of anticancer drugs

    Författare :Helena Fridborg; Uppsala universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : .... LÄS MER

  5. 19. Exploring thioredoxin reductase as an anticancer drug target

    Författare :Stefanie Prast-Nielsen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Mammalian thioredoxin reductase (TrxR; EC 1.8.1.9) is a homodimeric NADPH-dependent selenium-containing flavoenzyme with disulfide oxidoreductase activity. LÄS MER

  7. 20. Molecular mechanisms and targets of new anticancer treatments

    Författare :Amirata Saei Dibavar; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The work presented in this thesis is an effort to decipher and understand the mechanism of action (MOA) of anticancer agents by building on and complementing chemical proteomics methods. The backbone of the thesis relies on a recent method called Functional Identification of Target by Expression Proteomics (FITExP) developed in Zubarev lab, where drug induced proteomic signatures are analyzed in various cell lines and top differentially regulated proteins with consistent behavior are determined, among which the drug target and mechanistic proteins are usually present. LÄS MER