Sökning: "Active transport"

Visar resultat 16 - 20 av 440 avhandlingar innehållade orden Active transport.

  1. 16. Pharmacokinetics and Pharmacodynamics of Oxycodone and Morphine with Emphasis on Blood-Brain Barrier Transport

    Författare :Emma Boström; Margareta Hammarlund-Udenaes; Ulrika Simonsson; Danny D Shen; Uppsala universitet; []
    Nyckelord :Pharmacokinetics Pharmacotherapy; pharmacokinetics; pharamcodynamics; blood-brain barrier; oxycodone; microdialysis; NONMEM; brain distribution; transport; Farmakokinetik Farmakoterapi;

    Sammanfattning : The pharmacokinetics and pharmacodynamics of oxycodone and morphine was investigated and related to the transport across the blood-brain barrier (BBB) in rats. The influence of a P-glycoprotein (P-gp) inhibitor on the plasma pharmacokinetics and pharmacodynamics of oxycodone was evaluated. LÄS MER

  3. 17. Studies on bikeability in a metropolitan area using the active commuting route environment scale (ACRES)

    Författare :Lina Wahlgren; Peter Schantz; Henrik Gustafsson; Pekka Oja; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; active transport; bicycle commuting; bikeability; multiple linear regression analysis; perception; reliability; route environment; validity; Sports; Idrott; Sports Science; Idrottsvetenskap; Samhällsvetenskap Humaniora;

    Sammanfattning : Background: The Active Commuting Route Environment Scale (ACRES) was developed to study active commuters’ perceptions of their route environments. The overall aims were to assess the measuring properties of the ACRES and study active bicycle commuters’ perceptions of their commuting route environments. LÄS MER

  4. 18. Hepatic Disposition of Drugs and the Utility of Mechanistic Modelling and Simulation

    Författare :Erik Sjögren; Hans Lennernäs; Scott Obach; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hepatic disposition; pharmacokinetics; mechanistic modelling; drug-drug interactions; enzyme kinetics; Vmax; Km; CLint; carrier-mediated transport; active transport; modelling; in vitro-in vivo extrapolation; physiologically based pharmacokinetic model; optimal experimental design; experimental optimization; data analysis optimization; PHARMACY; FARMACI; Biopharmacy; Biofarmaci; Biopharmaceutics; Biofarmaci;

    Sammanfattning : The elimination of drugs from the body is in many cases performed by the liver. Much could be gained if an accurate prediction of this process could be made early in the development of new drugs. However, for the elimination to occur, the drug molecule needs first to get inside the liver cell. LÄS MER

  5. 19. Blood-Brain Barrier Transport of Drugs Across Species with the Emphasis on Health, Disease and Modelling

    Författare :Karin Tunblad; Margareta Hammarlund-Udenaes; Niclas Jonsson; Elizabeth CM de Lange; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Blood-brain barrier; Disease; Microdialysis; Modelling; Transport; Pharmacokinetics; NONMEM; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci;

    Sammanfattning : The transport of drugs across the blood-brain barrier (BBB) has been investigated in different species using morphine and morphine-6-glucuronide (M6G) as model compounds. The influence of probenecid on the BBB transport of morphine and M6G was investigated, and the consequences of meningitis and severe brain injury on the concentrations of morphine in the brain were examined. LÄS MER

  7. 20. Studies of Charge Transport and Energy Level in Solar Cells Based on Polymer/Fullerene Bulk Heterojunction

    Författare :Abay Gadisa; Olle Inganäs; Vladimir Dyakonov; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Bulk heterojunction; Charge transport; Space charge limited; Bipolar transport; Origin of open circuit voltage; Polymer-fullerene blend; Soft contact lamination; Polarized infrared emission; Physics; Fysik;

    Sammanfattning : π-Conjugated polymers have attracted considerable attention since they are potential candidates for various opto-electronic devices such as solar cells, light emitting iodes, photodiodes, and transistors. Electronic de vices based on conjugated polymers can be easily processed at low temperature using inexpensive technologies. LÄS MER