Sökning: "warfarin"

Visar resultat 26 - 30 av 64 avhandlingar innehållade ordet warfarin.

  1. 26. CYP2C-dependent drug metabolism in vivo : influence of genetics and drug interactions

    Författare :Staffan Rosenborg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cytochrome P450 enzymes (CYPs) are responsible for the metabolism of the majority of therapeutic drugs. This thesis focuses on one of the CYP subfamilies, CYP2C, especially CYP2C9 and CYP2C19, which are responsible for the metabolism of 15– 20% of all drugs. All CYP2C enzymes are polymorphic, i.e. LÄS MER

  3. 27. Sex differences in adverse drug events from cardiovascular medicines in routine care

    Författare :Diana Rydberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In preventive drug treatment of cardiovascular disease, adverse drug effects often lead to suboptimal compliance with a risk of disability and shorter life expectancy. The overall aim of this thesis was to assess the nature and extent of adverse drug events (ADEs) from cardiovascular drugs in both women and men treated in routine care. LÄS MER

  4. 28. Intracerebral hemorrhage in patients treated with intravenous thrombolysis for acute ischemic stroke

    Författare :Michael V Mazya; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background. Nearly 30000 people suffer a stroke in Sweden every year. Stroke is the third most common cause of death after heart disease and cancer carrying a 17% mortality rate at three months. It is the most common cause of neurological disability in adults. LÄS MER

  5. 29. Prevalence of drug-drug interactions and clinical relevance for treatment with oral anticoagulants

    Författare :Johan Holm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The aim of this thesis was to describe prevalences and frequencies of potential DDIs in the Swedish outpatient population, and the clinical effects in treatment with oral anticoagulants. Two cross-sectional studies were conducted to establish the prevalence and frequency of potential DDIs among Swedish outpatients. LÄS MER

  7. 30. CYP2C19 polymorphisms in drug metabolism and response

    Författare :Ming Chang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Individuals vary widely in their response to drug treatment. After receiving doses of a drug that are recommended based on a population average, some patients could have an insufficient response, whereas others may experience adverse effects. LÄS MER