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1. 1. Processing and presentation of exogenous antigen by dendritic cells

   Författare :Liying Chen; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :DC; vesicular MHC-I processing; Adenosine; CD 1 d; TACA;

   Sammanfattning : Dendritic cells (DC) play a key role in the immune system. In this thesis, we have investigated and characterized pathways for the processing and presentation of exogenous OVA on MHC-I ("cross-presentation") and how these were influenced by the purine nucleoside Adenosine (Ado), an immune regulator that accumulates to high concentrations at sites of inflammation and tumor growth. LÄS MER