Sökning: "stress-activated kinases"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden stress-activated kinases.

  1. 1. On the role of SAP kinase pathways in cellular responses to cancer treatment

    Författare :Kristina Viktorsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Signal transduction; apoptosis; stress-activated kinases; cisplatin; ionizing radiation;

    Sammanfattning : Inherited or acquired resistance to therapy is a major clinical problem in the treatment of cancer. Defective apoptosis signalling is increasingly acknowledged as an important mechanism of resistance. Better understanding of apoptosis regulation may therefore help improve therapy. LÄS MER

  3. 2. Adenosine receptor signaling and the activation of mitogen-activated protein kinases

    Författare :Gunnar Schulte; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The nucleoside adenosine is present in all cells and body fluids of all living organisms; its production, both intracellularly and extracellularly, is tightly coupled to energy consumption resulting in increasing extracellular adenosine levels with increased energy consumption. Adenosine is metabolized by adenosine deaminase and adenosine kinase. LÄS MER

  4. 3. Downstream functions of the Sty1 MAPK pathway in S. pombe

    Författare :Eva Asp; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; S.pombe; MAPK; Sty1; Mkp1; oxidative stress; translation; mRNA stability;

    Sammanfattning : MAP kinase pathways are involved in the response to environmental changes in eukaryotic cells regulating transcriptional and translational events. In S. LÄS MER

  5. 4. L-DOPA-induced signaling pathways and neuroepigenetic mechanisms in experimental parkinsonism and dyskinesia

    Författare :Michael Feyder; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In patients with Parkinson’s disease (PD), the restoration of depleted striatal dopamine by chronic administration of its precursor, L-DOPA, results in the emergence of debilitating involuntary movements. This complication, termed L-DOPA-induced dyskinesia (LID), represents a limitation to the most efficacious treatment for PD motor symptoms. LÄS MER

  7. 5. Apoptotic signaling in lung carcinoma cells : with focus on mechanisms of radioresistance

    Författare :Jessica Ekedahl; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In this thesis, IR-induced apoptotic signaling was studied in a panel of lung carcinoma cell lines. The goal was not only to achieve a better understanding of the process, but also to identify possible targets for pharmacological modulation to enhance the efficiency of radiotherapy. LÄS MER