Sökning: "pseudocapsids"

Hittade 2 avhandlingar innehållade ordet pseudocapsids.

1. 1. Murine polyomavirus VP1 virus-like particles as vectors for gene therapy and as vaccines against polyomavirus infection and tumors

   Författare :Andrea Vlastos Franzén; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Polyomavirus; virus-like particles; pseudocapsids; gene therapy; vaccines; tumors;

   Sammanfattning : Murine polyomavirus (MPyV) is a double stranded DNA virus ubiquitous in mice. The virus genome encodes for three transforming antigens that interact with the host cell machinery in order to initiate viral production. The transforming antigens can under certain circumstances when not controlled, e.g. LÄS MER

3. 2. Studies on persistent polyomavirus infection in relation to tumor development and options for vaccine and gene therapy

   Författare :Shirin Heidari; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Polyomavirus is a small DNA virus capable of inducing tumors in mice with a defective or an immature immune system. The importance of T-cells in prevention of polyoma-induced tumor development has previously been shown. In this thesis, we wished to elucidate the role of humoral immunity with regard to polyomavirus persistence and tumor development. LÄS MER