Sökning: "multicellular tumor spheroids"

Visar resultat 6 - 10 av 11 avhandlingar innehållade orden multicellular tumor spheroids.

  1. 6. Mechanisms of multicellular drug resistance and novel approaches for targeted therapy in cancer

    Författare :Elin Edsbäcker; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Dysregulated gene expression, due to genetic and epigenetic aberrations, as well as cancer cell-stroma interactions underlie both tumorigenesis and resistance to anti-cancer therapy. Although governed by common mechanisms, these features are unique to each individual tumor and therefore a personalized treatment regimen needs to be composed for each patient. LÄS MER

  3. 7. Using a 3-d model system to screen for drugs effective on solid tumors

    Författare :Walid Fayad; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : There is a large medical need for the development of effective anticancer agents with minimal side effects. The present thesis represents an attempt to identify potent drugs for treatment of solid tumors. LÄS MER

  4. 8. Different approaches to develop radio- and chemotherapy for treatment of human cancer

    Författare :Chitralekha Mohanty; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Despite huge advancements in our knowledge and understanding of the molecular mechanisms of carcinogenesis, the prognoses of many malignant diseases have not improved dramatically. Improvements in the therapeutic efficacy of several anti-cancer therapies including radiotherapy and chemotherapy would be required to achieve effective treatment. LÄS MER

  5. 9. The role of autophagy in anticancer therapy

    Författare :Matheus Dyczynski; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Autophagy is a fundamental catabolic process, which is utilized by nearly every cell and tissue type upon stress exposure and has been shown to contribute to resistance to chemotherapy in a variety of cancers. The subject of this thesis is to shed light on the role of autophagy in chemotherapy and to investigate novel regulators of autophagy. LÄS MER

  7. 10. Urinary bladder carcinoma, preclinical and clinical studies on EGFR based targeting

    Författare :Peter Bue; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; urinary bladder carcinoma; epidermal growth factor-dextran; radionuclide therapy; Kirurgi; Surgery; Kirurgi; kirurgi; särskilt urologi; Urology;

    Sammanfattning : Radical cystectomy with bilateral pelvic lymphadenectomy is the standard treatment for muscle-invasive transitional cell carcinoma of the urinary bladder. Despite presumably localised malignancies and efficacious management about 50% of patients will die within 5 years, the majority due to metastatic disease. LÄS MER