Sökning: "Melanoma 2020"

Visar resultat 1 - 5 av 18 avhandlingar innehållade orden Melanoma 2020.

  1. 1. Molecular characterization of the immune microenvironment in melanoma

    Författare :Rita Cabrita; Melanoma Genomics; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Melanoma; Immune microenvironment; Tertiary lymphoid structures; Immunotherapy; Immune evasion; Methylation; Immune gene signatures;

    Sammanfattning : .... LÄS MER

  3. 2. Exploring the Molecular Landscape of Cutaneous Melanoma

    Författare :Shamik Mitra; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Melanoma; Immune System; Tumor Microenvironment; Epigenetics; MITF; SOX10;

    Sammanfattning : Cutaneous malignant melanoma (CMM) is one of the most aggressive skin malignancies with poor prognosisfor the patients with metastatic disease. Earlier studies have highlighted the existing molecular diversityamongst CMM tumors. LÄS MER

  4. 3. The Role of Melanocyte Lineage Genes in Melanoma

    Författare :Adriana Sanna; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Melanoma; Genetic; Epigenetic; Heterogeneity; MITF; SOX10; CSD;

    Sammanfattning : Malignant melanoma accounts for the highest number of deaths among all skin cancer types, and its incidence has increased dramatically over the past decades. Despite the tremendous therapeutic advances, treatment resistant cells emerge in the vast heterogeneity of melanoma, driving tumor relapse and poor patient outcome. LÄS MER

  5. 4. Translational studies of metastatic melanoma in the era of immunotherapy - from humanized mouse models to clinical trials

    Författare :Henrik Jespersen; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Metastatic melanoma; Uveal melanoma; Humanized mouse models; Immunotherapy; Chimeric antigen receptor T cells; PD-1 inhibition; Epigenetics; Histone deacetylase inhibition;

    Sammanfattning : Immunotherapy with PD-1 inhibitors has transformed the treatment of met-astatic cutaneous mela- noma, and can lead to complete and durable responses in a proportion of patients. However, in around half of the patients, the treatment has little or no effect. LÄS MER

  7. 5. Immunometabolic network interactions of the kynurenine pathway in cutaneous malignant melanoma

    Författare :Soudabeh Rad Pour; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cancer is the second leading cause of mortality worldwide, and melanoma represents the most aggressive and deadliest form of skin cancer. Despite the various therapeutic approaches, metastatic melanoma is a disease with a poor prognosis. LÄS MER