Sökning: "Melanoma Genomics"

Hittade 4 avhandlingar innehållade orden Melanoma Genomics.

  1. 1. Molecular characterization of the immune microenvironment in melanoma

    Författare :Rita Cabrita; Melanoma Genomics; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Melanoma; Immune microenvironment; Tertiary lymphoid structures; Immunotherapy; Immune evasion; Methylation; Immune gene signatures;

    Sammanfattning : .... LÄS MER

  3. 2. Computational exploration of cancer genomes

    Författare :Joakim Karlsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Cancer genomics; Transcriptomics; Driver genes; Copy number changes; Immunogenomics; Cancer of unknown primary; Uveal melanoma;

    Sammanfattning : Cancer evolves due to changes in DNA that give a cell an advantage at the expense of the remaining organism. These alterations range from individual base substitutions to broad losses or duplications of chromosomal material. LÄS MER

  4. 3. Genomic mutational heterogeneity in cancer. lmproved models and tools for driver gene detection

    Författare :Martin Boström; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer; genomics; ultraviolet light; mutational heterogeneity;

    Sammanfattning : Cancer is a disease that is strongly related to evolution, as mutations that confer a benefit to individual cells face positive selection and eventually lead to tumorigenesis. As such, the search for genes that drive cancer development entails distinguishing positive selection from other sources of increased mutation rates, which requires detailed knowledge of how normal mutation rates vary across the genome. LÄS MER

  5. 4. Approaches for analysis of mutations and genetic variations

    Författare :Afshin Ahmadian; KTH; []
    Nyckelord :LOH; microsatellite; fragment analysis; DNA sequencing; pyrosequencing; cancer; mutation; variation; SNP; allele-specific extension; apyrase; TECHNOLOGY; TEKNIKVETENSKAP;

    Sammanfattning : Detecting mutations and genomic variations is fundamental indiagnosis, isolating disease genes, association studies,functional genomics and pharmacogenomics. The objective hasbeen to use and further develop a variety of tools andtechnologies to analyze these genetic alterations andvariations. LÄS MER