Sökning: "LDLR"

Visar resultat 6 - 10 av 27 avhandlingar innehållade ordet LDLR.

  1. 6. Hormonal influences on cholesterol and bile acid metabolism : focusing on involvement of PCSK9

    Författare :Moumita Ghosh Laskar; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Elevated plasma LDL-C is today considered a causative factor for the development of atherosclerosis. Increased plasma LDL-C levels are mainly due to reduced numbers of functional LDL receptors (LDLRs) in the liver. LÄS MER

  3. 7. Cardiac troponin T in clinical and experimental studies

    Författare :Christian Löwbeer; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The cardiac troponin T (cTnT) assay became commercially available in the 1990s, and together with cardiac troponin I (cTnI), cTnT is today the marker of choice for the detection of myocardial infarction. However, when the cTnT assay was introduced it was insufficiently evaluated in two important fields: in patients with renal disease and in experimental cardiovascular research. LÄS MER

  4. 8. Familial hypercholesterolemia in Sweden : genetic and clinical studies

    Författare :Peter Benedek; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Prevention of premature disease and death from cardiovascular complications of atherosclerosis is an important goal for public health, and the early identification of individuals with increased risk is an important goal of modern medicine. Familial hypercholesterolemia (FH) is one of the most common monogenic diseases (1/250 to 1/300) where strong evidence of positive health effects of intervention has been established. LÄS MER

  5. 9. Targeting the role of statins in breast cancer – through translationally edged clinical trials

    Författare :Maria Feldt; Bröstcancer - prevention & intervention; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : AbstractBreast cancer incidence is increasing, and despite major progress in the treatment, breast cancer is still the leading cause of death from cancer among women. Thus, there is a constant need for new treatment options. LÄS MER

  7. 10. Cellular immune responses to low density lipoprotein in atherosclerosis

    Författare :Andreas Hermansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Atherosclerosis is an inflammatory disease of the medium and large sized arterial vessels. Low density lipoprotein (LDL) particles carrying cholesterol are trapped within the arterial intima and elicit both innate as well as adaptive immune responses. LÄS MER