Sökning: "virtual screening"
Visar resultat 21 - 25 av 37 avhandlingar innehållade orden virtual screening.
21. The osteogenic potential of human mesenchymal stem cells: Novel markers and key factors for differentiation
Sammanfattning : Mesenchymal stem cells are multipotent stem cells with ability to differentiate into cells of the connective tissue lineage, such as adipocytes, osteoblasts and chondrocytes, both in vitro and in vivo. The main objective of the present thesis was to study different aspects of the osteogenic potential of MSCs. LÄS MER
22. Structural Studies of Glutamine Synthetases – Towards the Development of Novel Antitubercular Agents
Sammanfattning : Glutamine synthetase (GS) plays an important role in nitrogen metabolism, where it catalyzes the ATP-dependent condensation of glutamate and ammonia to yield glutamine. Recent studies showed the importance of M. tuberculosis GS (MtGS) for growth and survival of the bacterium, and demonstrated its potential as a drug target. LÄS MER
23. Synthesis of Small Molecules Targeting ADP-Ribosyltransferases and Total Synthesis of Resveratrol Based Natural Products
Sammanfattning : Diphtheria Toxin-like ADP-RibosyltransferasesThe Human ADP-ribosyl transferases (ARTDs) are a group of poorly studied enzymes which are believed to be involved in e.g. DNA repair, protein degradation, transcription regulation and cell death. Medicinal chemistry programmes aimed at developing selective inhibitors of these ARTDs were initiated. LÄS MER
24. Failure prediction of orthotropic Non-Crimp Fabric reinforced composite materials
Sammanfattning : The automotive industry needs to reduce the energy consumption to decrease the impact on the environment. One part of this is to reduce the weight of cars, thereby reducing the fuel consumption. A promising way to be successful with this is to introduce carbon fibre composites in the structural parts. LÄS MER
25. Structural and functional studies of proteins of medical relevance : Protein-ligand complexes in cancer and novel structural folds in bacteria
Sammanfattning : X-ray crystallography is a tool for determining the structures of proteins and protein-ligand complexes. In this thesis the method has been employed to study several proteins of medical relevance.Cancer is a terrible disease, severely impacting those affected, as well as their family and friends. LÄS MER