Sökning: "tyrosine phosphatases"

Visar resultat 11 - 15 av 21 avhandlingar innehållade orden tyrosine phosphatases.

  1. 11. A multifaceted study of the receptor tyrosine kinase Axl with focus on Renal Cell Carcinoma

    Författare :Anna Gustafsson; Malmö Klinisk kemi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The present investigation is a multifaceted study of the receptor tyrosine kinase Axl, whose overexpression and activation is implicated in several human malignancies, with focus on renal cell carcinoma (RCC). At first, our main interest concerned the intracellular Axl interactor named Tensin2 (Tns2) and its family member Tensin3 (Tns3). LÄS MER

  3. 12. Modulation of PDGF Receptor Signaling via the Phosphatase SHP-2 and the Docking Protein Gab1

    Författare :Anders Kallin; Lars Rönnstrand; Carl-Henrik Heldin; Per Lindahl; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; PDGF; SHP-2; Gab1; chemotaxis; actin reorganization; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi;

    Sammanfattning : x.... LÄS MER

  4. 13. Reciprocal regulation of endocytosis and signaling in Drosophila epithelial development and aberrant growth

    Författare :Dan Liu; Christos Samakovlis; Vasilios Tsarouhas; Héctor Herranz; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; endocytosis; protein sorting; RTK signaling; airway maturation; tumor-suppressive cell competition; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : Endocytosis and subsequent endosomal sorting of plasma membrane proteins and nutrients are essential for cellular homeostasis. Previous work has uncovered several different internalization mechanisms, endosomal sorting routes and aspects of their regulation. LÄS MER

  5. 14. Redox-regulation of PTPs : mechanisms and impact on PDGFR signaling

    Författare :Markus Dagnell; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Protein tyrosine phosphatases (PTPs) are reversibly oxidized upon activation of platelet-derived growth factor receptor beta (PDGFβR). Dys-regulation of the PDGFβR signaling pathway is associated with several diseases, including cancers and cardiovascular disease, and is thus a known driver of disease progression. LÄS MER

  7. 15. Structural studies of three cell signaling proteins : crystal structures of EphB1, PTPA, and YegS

    Författare :Amin Bakali; Pär Nordlund; Wenqing Xu; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein production; structural genomics; cell signaling; Biochemistry; Biokemi;

    Sammanfattning : Kinases and phosphatases are key regulatory proteins in the cell. The disruption of their activities leads ultimately to the abolishment of the homeostasis of the cell, and is frequently correlated with cancer. EphB1 is a member of the largest family of receptor tyrosine kinases. It is associated with neurogenesis, angiogenesis, and cancer. LÄS MER