Sökning: "tyrosine phosphatases"

Visar resultat 6 - 10 av 21 avhandlingar innehållade orden tyrosine phosphatases.

1. 6. T-Cell Protein Tyrosine Phosphatase, a Regulator of the PDGF Signaling Pathway

   Författare :Susann Karlsson; Carina Hellberg; Carl-Henrik Heldin; Bengt Hallberg; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PDGF; TC-PTP; receptor trafficking; PK-M2; Medical cell biology; Medicinsk cellbiologi; molekylär cellbiologi; Molecular Cellbiology;

   Sammanfattning : Platelet-derived growth factor (PDGF) is a potent stimulator of cell growth, survival and motility. PDGF exerts its function by binding to specific tyrosine kinase receptors, initiating receptor auotphosphorylation and initiation of specific signaling pathways that regulates the cellular response. LÄS MER

3. 7. Computer Simulation of Protein Tyrosine Phosphatase Reaction Mechanisms and Dihydrofolate Reductase Inhibition

   Författare :Karin Kolmodin; Ernst-Walter Knapp; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; Molecular Biotechnology; Molekylär bioteknik;

   Sammanfattning : Protein tyrosine phosphatases catalyse the hydrolysis of phosphotyrosine residues in proteins, which is an important reaction in the cell signalling system. The three dimensional structure of such a protein tyrosine phosphatase has been used in a computational study of the reaction mechanism at the atomic level. LÄS MER

4. 8. Structural and Functional Studies of the Density Enhanced Receptor-like Protein Tyrosine Phosphatase DEP-1

   Författare :Maria Sörby; Jeroen Hertog; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Onkologi; Oncology; Onkologi; molekylär cellbiologi; Molecular Cellbiology;

   Sammanfattning : Tyrosine phosphorylation is a central mechanism in cellular signalling leading to proliferation, migration or differentiation. Protein tyrosine phosphorylation is regulated by the coordinated actions of protein tyrosine kinases and protein tyrosine phosphatases. LÄS MER

5. 9. Role of protein-tyrosine phospatases in insulin and glucagon secretion in pancreatic islets of healthy rats and spontaneously diabetic GK rats

   Författare :Jie Chen; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Protein-tyrosine phosphatase; insulin; glucagon; vanadate; type 2 diabetes; pancreatic islets;

   Sammanfattning : Both insulin and glucagon secretion from pancreatic beta- and alpha-cells, respectively, are regulated by nutrients such as glucose and amino acids. In addition, the mechanisms leading to exocytosis of hormones are influenced by kinases and phosphatases that phosphorylate and dephosphorylate regulatory proteins respectively. LÄS MER

7. 10. Ligand binding and enzyme catalysis studied by molecular dynamics simulations

   Författare :Tomas Hansson; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; molecular dynamics simulation; free energy; linear response; drug design; empirical valence bond; HIV protease; protein tyrosine phosphatase; Molekylärbiologi; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

   Sammanfattning : Molecular dynamics simulations and free energy calculations can be applied to biomolecular systems to predict ligand binding affinities. Combined with hybrid quantum-classical potential energy surfaces, such computations can also be used to probe enzymatic catalysis mechanisms. LÄS MER