Sökning: "Magnus Wolf-Watz"

Visar resultat 1 - 5 av 14 avhandlingar innehållade orden Magnus Wolf-Watz.

  1. 1. Determining the effects of regulatory parameters on the structural dynamics of P-type ATPase membrane transporters

    Författare :Fredrik Orädd; Magnus Andersson; Magnus Wolf-Watz; Marco Cammarata; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; protein dynamics; regulation; time-resolved x-ray solution scattering; MD simulation; membrane protein; P-type ATPase; SERCA; CopA; HMA4; adenylate kinase; Physical Chemistry; fysikalisk kemi;

    Sammanfattning : Proteins are macromolecular machines with roles in all cellular activities and structures. The functional properties of each protein is the result of its combination of 3D-structure and inherent dynamics, and a wealth of structural and dynamic mechanisms have evolved to regulate protein activity. LÄS MER

  3. 2. Structure-function relationships of the human Runx1 transcription factor

    Författare :Magnus Wolf-Watz; KTH; []
    Nyckelord :Runx1; Runt domain; CBFâ; transcription; leukemia; protein structure; protein dynamics;

    Sammanfattning : Runx transcription factors contain a DNA-binding andtransactivating α-subunit and a β-subunit (CBFβ)that serves to increase the DNA binding affinity of theα-subunit. The DNA binding domain of Runx proteins isnamed the Runt homology domain (RD) after its strong sequencehomology to theDrosophilaprotein Runt. LÄS MER

  4. 3. Modulation of amyloid β peptide self-assembly : Aggregation mechanisms associated with Alzheimer's disease

    Författare :Axel Abelein; Astrid Gräslund; Magnus Wolf-Watz; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biophysics; biofysik;

    Sammanfattning : .... LÄS MER

  5. 4. The role of RNA in prion aggregation and disease

    Författare :Petar Stefanov Kovachev; Suparna Sanyal; Per Jemth; Magnus Wolf-Watz; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molekylär cellbiologi; Molecular Cellbiology;

    Sammanfattning : As humanity evolved to witness an exceptionally high standard of living, Alzheimer’s, cancer and diabetes gradually replaced infections as the main limiting factors in longevity. It is both disturbing and captivating that such degenerative conditions are caused by the most ubiquitous biomolecule – the protein. LÄS MER

  7. 5. How transient interactions in the crowded cytosol affect protein mobility and stability

    Författare :Sarah Leeb; Mikael Oliveberg; Magnus Wolf-Watz; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; diffusive transient interactions; macromolecular crowding; protein stability; in-cell NMR; protein evolution; Biophysics; biofysik;

    Sammanfattning : Most biochemical reactions have evolved in crowded intracellular environments. However, the complexity of intracellular environments is often neglected in structural or functional studies of proteins. LÄS MER