Sökning: "tissue-resident"

Visar resultat 1 - 5 av 40 avhandlingar innehållade ordet tissue-resident.

  1. 1. Lung-resident, M2e-specific CD4 T cells critically protect during influenza infection

    Författare :Ajibola Omokanye; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; influenza; vaccine; universal; heterosubtypic; M2e; CD4; Th17; ThCTL; tissue-resident; cytotoxic; single-cell RNA-seq;

    Sammanfattning : Memory CD4+ T cells are a critical component of the adaptive immune response to fight infection. However, current vaccines against influenza only focus on the other arm of adaptive immunity—triggering B cells to produce antibodies. LÄS MER

  3. 2. Macrophages in Crohn's Disease: lnnate immune cellular and molecular mechanisms driving intestinal inflammation and fibrosis

    Författare :Frida Gorreja; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; macrophages; inflammatory macrophages; tissue-resident macrophages; efferocytosis; innate immunity; myeloid cells; fibroblasts; fibrosis; inflammasomes; Crohn´s disease; inflammatory bowel diseases; digestive diseases; mucosa immunology; intestinal immunity; intestinal inflammation; serum systemic inflammation; microbiota; metabolites;

    Sammanfattning : Macrophages and their interactions with the lamina propria and luminal microenvi-ronment are crucial in the pathogenesis of Crohn´s disease (CD), a chronic inflamma-tory disease with a strong inflammatory innate immune involvement. Therefore, in-terpreting macrophage activity in the intestinal microenvironment may identify treatment targets beneficial for at least a subgroup of patients. LÄS MER

  4. 3. Studies of the Pancreas: Implications for Type 1 Diabetes Aetiology

    Författare :Peter Seiron; Oskar Skog; Michele Solimena; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pancreas; Type 1 Diabetes; Insulitis; Beta cells; Immunology; Tissue resident memory T cells; Islets of Langerhans; Endocrinology and Diabetology; Endokrinologi och Diabetologi; Immunologi; Immunology;

    Sammanfattning : Type 1 diabetes (T1D) is a disease of severe insulin deficiency through loss of β cells in the endocrine pancreas. The T1D dogma maintains that a precipitating event unleashes autoimmunity in at-risk individuals, often measured through autoantibodies against β cell antigens. LÄS MER

  5. 4. Immune cell composition and cytokine expression in the pregnant and non-pregnant uterus

    Författare :Ylva Crona Guterstam; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The success of implantation and further development of the embryo is heavily dependent on the endometrial immune cell composition and its ability to communicate with fetal semi-allogeneic trophoblast cells. Although our understanding of the immune cell population in the uterus has improved, its precise role in normal reproduction and reproductive disorders is still not fully resolved. LÄS MER

  7. 5. The role of liver myeloid cells in obesity and metabolic disease

    Författare :Emelie Barreby; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Macrophages are tissue resident cells with diverse phenotypes and functions depending on their origin, localization and physiological context. In the liver, their main functions are to detoxify the blood from pathogens, debris and metabolic waste arriving to the liver through the systemic and portal circulation. LÄS MER