Sökning: "startle habituation"
Hittade 5 avhandlingar innehållade orden startle habituation.
1. Fear, Startle, and Fear-Potentiated Startle : Probing Emotion in the Human Brain
Sammanfattning : The present thesis explored the neurobiological basis of three aspects of defense behaviors in humans. Positron emission tomography methodology was used, and changes in regional cerebral blood flow (rCBF) were measured as an index of neural activity. LÄS MER
2. Cognitive function studied in animal models of schizophrenia
Sammanfattning : Cognitive dysfunction is considered a core deficit of schizophrenia, which currently lacks effective pharmacological treatment. In order to identify novel and more effective drug treatments, translational experimental animal models of cognitive dysfunction are required. Schizophrenia-like symptoms can be induced in humans by phencyclidine (PCP). LÄS MER
3. Schizophrenia and Nitric Oxide: Deficits in Information Processing Invetigated in Animal Models
Sammanfattning : Rationale: Schizophrenia-like symptoms can be induced in humans by phencyclidine (PCP), a non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor. Schizophrenic patients and PCP-treated animals display deficits in pre-attentive information processing, as assessed by e.g. prepulse inhibition of the acoustic startle response. LÄS MER
4. Genetic gating of human fear, fear learning and extinction : psychophysiological, brain imaging (fMRI) and clinical studies
Sammanfattning : Individuals differ in their reaction to the same environmental stressor. After being opposed to the same trauma, some individuals will develop affective pathologies, while others will not. This is assumed to result, at least partly, from a differential genetic vulnerability. LÄS MER
5. Cognition and social behaviour in schizophrenia: An animal model investigating the potential role of nitric oxide
Sammanfattning : Cognitive deficits are the single strongest predictor of functional outcome in patients with schizophrenia. Furthermore, these deficits are not satisfactorily alleviated by available antipsychotic treatment. LÄS MER