Sökning: "sodium channel"

Visar resultat 11 - 15 av 46 avhandlingar innehållade orden sodium channel.

1. 11. Development and regulation of alveolar fluid clearance in the guinea pig

   Författare :Andreas Norlin; Biologiska institutionen; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; oxytocin-induced preterm labor; IRDS; fetal lung fluid; preterm lung development; amiloride-sensitive sodium channels; beta-adrenergic stimulation; alveolar epithelium; Animal physiology; Djurfysiologi;

   Sammanfattning : Alveolar fluid clearance is driven by active absorption of Na+ across the alveolar epithelium. Development and hormonal regulation of alveolar fluid clearance over 1 hour was studied by instillation of a protein-containing, isosmolar fluid into lungs of fetal, newborn, and adult guinea pigs. LÄS MER

3. 12. Structure and function of trigeminal primary sensory neurons after peripheral nerve injury

   Författare :Ulf Bongenhielm; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :ankyrinG; chronic constriction injury; electron microscopy; electrophysiology; hyperexcitability; immunocytochemistry; inferior alveolar nerve; in situ hybridisation; nerve injury; neuroma; SNS PN3; sodium channel; trigeminal ganglion;

   Sammanfattning : Iatrogenic injuries to branches of the trigeminal nerve are common during surgical procedures in the jaws and teeth, and as the repercussion of facial fractures or certain pathologies. A portion of these patients are left with disturbed sensory functions, and some with unpleasant abnormal sensations, including pain. LÄS MER

4. 13. Cardiovascular and sympatho-adrenal responses to mental stress with special reference to the regulation of human forearm blood flow

   Författare :Madeleine Lindqvist; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :adrenaline; axillary blockade; beta-receptor blockader; calcium channel blockers; cholinergic blockingagents; felodipine; hypertension-primary; noradrenaline; skeletal muscle; sodium nitroprusside; stress-psychologicai; vascular resistance;

   Sammanfattning : The cardiovascular and sympatho-adrenal responses to a standardized mental stress test (Stroop's colour word conflict test CWT) were studied in 63 healthy and 11 hypertensive men by intraarterial pressure measurements, forearm blood flow by occlusion plethysmography and noradrenaline (NA) and adrenaline (ADR) determinations in arterial and venous plasma. One study included central hemodynamics by right heart catheterization and NA turnover by an isotope dilution method, permitting studies of NA kinetics in the whole body and in a regional vascular bed (the forearm) in hypertensive patients and age-matched controls. LÄS MER

5. 14. Ion channels in drug discovery : focus on biological assays

   Författare :Kim Dekermendjian; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Ion channels; GABAA receptor; sodium channels; TRPM8; drug discovery; high throughput screening assays; FLIPR; automated electrophysiology;

   Sammanfattning : Ion channels are well characterised drug targets. However, the techniques used to study ion channel pharmacology have not been particularly applicable to modern drug discovery. LÄS MER

7. 15. Mechanisms of adaptation in a mechanoreceptor : a study of mechanical and ionic factors in the crayfish stretch receptors

   Författare :Nuhan Purali; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Crayfish; stretch receptor; adaptation; visco-elastic properties; mechanosensitive channels; potassium channels; sodium channels; gadolinium; tetraethylammonium chloride; 4-amino pyridine; scorpion venom Leiurus quinquestrialus;

   Sammanfattning : The stretch receptor organ of the crayfish, an analog to the human muscle spindle, is a unique preparation for the study of mechanotransduction. The organ consists of a rapidly and a slowly adapting receptor each composed of a receptor muscle fibre into which inserts the dendrites of a multipolar sensory neuron. LÄS MER