Sökning: "serine threonine"

Visar resultat 1 - 5 av 79 avhandlingar innehållade orden serine threonine.

  1. 1. Mechanisms of traumatic brain injury in the rat : Morphological consequences and neurotrophic responses

    Författare :Anders Lewén; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Cortical contusion injury; TBI; neurons; axons; dendrites; APP; MAP2; BMPR-II; ActR-I; trkB; c-fos; BDNF; PACAP; TUNEL; TGFs; serine threonine; bone morphogenetic protein; neuropeptides; reactive oxygen species; ROS; apoptosis; Neurovetenskap; Neurology; Neurologi; Neurosurgery; neurokirurgi;

    Sammanfattning : Traumatic brain injury is a major cause of death and disability in the Western world. especially in young people. Understanding the pathophysiology of traumatic brain injury is the basis for further development of better therapeutic strategies for such patients. LÄS MER

  3. 2. Protection of the developing brain with trophic factors. Signaling through serine/threonine kinase pathways

    Författare :Katarina Gustafson Brywe; Göteborgs universitet; []
    Nyckelord :hypoxia-ischemia; neonatal; brain; growth factors; ser thr kinases;

    Sammanfattning : Background: Perinatal asphyxia still constitutes a clinical hazard associated withconsiderable neurologic morbidity. There is today no therapy in clinical use toprotect the brain after such insult. LÄS MER

  4. 3. The developing rat kidney : the dopamine system and related serine/threonine kinases and phosphatases

    Författare :Johan Svennilson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :apoptosis; confocal immunofluorescence; DARPP-32; dopamine; foetal renal development; hypertension; in situ hybridization; metanephric culture; mouse; nephron number; PKC; PP1 PP2A; protein phosphorylation; rat;

    Sammanfattning : The kidney originates from the fusion and conversion of two tissues: the metanephric mesenchyme and the ureter epithelium, an evagination from the Wolffian duct. Although a number of candidate molecules have been shown to be of importance for the differentiation of the embryonic kidney, many of the signalling pathway leading to this development are still obscure. LÄS MER

  5. 4. Serine / threonine protein phosphatase 5 – a double-edged sword : in the progression towards diabetes

    Författare :Nina Grankvist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :diabetes;

    Sammanfattning : Type 2 diabetes mellitus is increasing at an alarming rate worldwide. In the development and progression of type 2 diabetes mellitus, the insulin-producing pancreatic β-cells are commonly exposed to a hyperglycemic and hyperlipidemic environment, in which the levels of reactive oxygen species are elevated. LÄS MER

  7. 5. Examining the role of metabolism in Myc-driven tumorigenesis

    Författare :Tacha Zi Plym Forshell; Jonas Nilsson; Mattias Belting; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; cancer; Myc; metabolism; polyamines; spermidine synthase; glycolysis; lactate dehydrogenase; serine metabolism; Phgdh; folate metabolism; Shmt; Pim kinase; Pim-3 Kinase; Molecular biology; Molekylärbiologi;

    Sammanfattning : Myc transcriptionally regulates genes involved in processes such as cell proliferation, metabolism, differentiation, and angiogenesis.  MYC expression is deregulated in many types of human cancer; therefore discovering the mechanisms behind MYCs role in tumorigenesis is essential. LÄS MER