Sökning: "reprogramming"

Visar resultat 21 - 25 av 100 avhandlingar innehållade ordet reprogramming.

  1. 21. Cell Replacement Therapy for Parkinson's Disease - Evaluating the potential of autologous grafting

    Författare :Fredrik Nilsson; Utvecklings- och regenerativ neurobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Stem and progenitor cells; Parkinson Disease; Alpha synuclein; Cell replacement therapies; Autologous stem cell transplantation; Direct reprogramming;

    Sammanfattning : .... LÄS MER

  3. 22. Impact of targeting MYC in metabolic reprogramming and differentiation of cancer

    Författare :Lourdes Sainero Alcolado; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Alterations in several metabolic pathways due to increased energy and biomass demand, as consequence of the uncontrolled proliferation of cancer cells, is known as metabolic reprogramming. Mutations in tumor suppressor genes and oncogenes that initiate cancer development, are responsible directly and indirectly of the changes in major cellular energy production processes, including glycolysis, glutaminolysis, and lipid metabolism. LÄS MER

  4. 23. Molecular mechanisms governing contraction-induced metabolic responses and skeletal muscle reprogramming

    Författare :Stephan Glund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :AMP-activated protein kinase; interleukin-6; exercise; glucose metabolism; lipid metabolism; adaptation to exercise.;

    Sammanfattning : Physical exercise enhances skeletal muscle responsiveness to insulin and regulates metabolism by an insulin-independent mechanism. Elucidation of contraction-mediated molecular mechanisms is imperative for a better understanding of skeletal muscle metabolism and function, and may lead to the identification or validation of possible drug targets for the prevention or treatment of metabolic disorders. LÄS MER

  5. 24. Directing and Dissecting the Fate of Dopaminergic Neurons - Multiple Avenues towards Cell Replacement Therapy in Parkinson's Disease

    Författare :Sara Nolbrant; Utvecklings- och regenerativ neurobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dopaminergic neurons; Cell replacement therapy; Parkinson s disease; Human pluripotent stem cells; Cell differentiation; Direct neuronal reprogramming; glial progenitors; midbrain development;

    Sammanfattning : .... LÄS MER

  7. 25. Manipulating neural stem cells

    Författare :Malin Eriksson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The stem cell field is a fairly young but fast growing scientific field. Our understanding of stem cells has changed tremendously over the last couple of decades. This in mainly due to the development of new techniques that has enabled us to study stem cells from a completely new perspective. LÄS MER