Sökning: "promoter selectivity"
Visar resultat 1 - 5 av 9 avhandlingar innehållade orden promoter selectivity.
1. Molecular mechanism of cell regulatory properties of vitamin D analogues in human cancer cell lines
Sammanfattning : The active form of vitamin D, 1α,25-dihydroxyvitamin D3, is a potent modulator of the induction of differentiation and inhibition of cell growth in both malignant and normal cells. Vitamin D and its analogues exert their effects through a transcription factor, the nuclear vitamin D receptor (VDR). LÄS MER
2. Molecular mechanisms of estrogen and antiestrogen action
Sammanfattning : Estrogen is a key regulatory hormone that affects numerous physiological processes. The estrogen receptors (ER), ER alpha and ER beta, play a central role in mediating the effects of both estrogens and antiestrogens. Estrogen signaling has proven to be multifaceted and the precise mechanism of action remains in many cases elusive. LÄS MER
3. Studies of penta-decameric binding proteins: AP-4 and CBF-A
Sammanfattning : Each immunoglobulin (Ig) V gene segment contains an upstream promoter region. The octamer element and the TATA box are the only elements that are conserved in all Ig promoters. The presence of the octamer element is necessary, but not sufficient to support high levels of transcription. LÄS MER
4. Estrogen signaling in metabolic disease : a functional genomics approach
Sammanfattning : Estrogens have traditionally been associated with female reproduction. More and more evidence has also linked estrogens to maintenance of glucose homeostasis and normal heart function. LÄS MER
5. Selective insulin signaling in the pancreatic beta-cell via the two insulin receptor isoforms
Sammanfattning : Insulin exhibits pleiotropic effects that are tissue- as well as development-dependent. However, the mechanisms by which insulin gains selective effects are poorly understood. Selectivity in insulin signaling is currently discussed as the result of the activation of specific signal transduction pathways. LÄS MER