Sökning: "vitamin D analogues"

Visar resultat 1 - 5 av 7 avhandlingar innehållade orden vitamin D analogues.

1. 1. Vitamin D Hydroxylating Enzymes and Analogues in Parathyroid Tumors and Breast Cancer

   Författare :Ulrika Segersten; Gunnar Westin; Per Hellman; Göran Åkerström; Martin Bäckdahl; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; hyperparathyroidism; breast cancer; vitamin D; CYP27B1; CYP24A1; vitamin D analogues; ketoconazole; vitamin D receptor; Kirurgi; Surgery; Kirurgi; Surgery; kirurgi;

   Sammanfattning : In hyperparathyroidism (HPT) raised serum concentrations of ionized calcium is caused by increased secretion of parathyroid hormone (PTH) by parathyroid tumors. Active vitamin D, 1α,25-dihydroxyvitamin D3, is known to suppress PTH secretion and to reduce proliferation of parathyroid tumor cells. LÄS MER

3. 2. Vitamin D and Vitamin D-binding Protein in Psoriasis and Effects of Treatment

   Författare :Maria Siekkeri Vandikas; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; psoriasis; vitamin D; vitamin D-binding protein; phototherapy; tumor necrosis factor α inhibitor;

   Sammanfattning : Background: Topical vitamin D analogues constitute an established treatment for psoriasis but the role of vitamin D in the pathogenesis of the disease remains controversial. The in loco production and immunomodulatory effects of vitamin D need to be elucidated. LÄS MER

4. 3. Molecular mechanism of cell regulatory properties of vitamin D analogues in human cancer cell lines

   Författare :Carina Danielsson; Uppsala universitet; []
   Nyckelord :Medical sciences; vitamin D analogues; retinoids; cancer cell lines; promoter selectivity; cellregulatory properties; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Dermatology and Venerology; dermatologi och venereologi;

   Sammanfattning : The active form of vitamin D, 1α,25-dihydroxyvitamin D3, is a potent modulator of the induction of differentiation and inhibition of cell growth in both malignant and normal cells. Vitamin D and its analogues exert their effects through a transcription factor, the nuclear vitamin D receptor (VDR). LÄS MER

5. 4. Expression and regulation of steroid metabolizing enzymes in cells of the nervous and skeletal systems : Special focus on vitamin D metabolism

   Författare :Mokhtar Almokhtar; Maria Norlin; Kjell Wikvall; Gösta Eggertsen; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

   Sammanfattning : Little is known about the mechanisms of vitamin D actions in the brain and bone. In this study, the metabolism of vitamin D and its regulation in various cell cultures of the nervous and skeletal systems were examined. LÄS MER

7. 5. The human antimicrobial protein hCAP18/LL37 in wound healing and cell proliferation

   Författare :Johan Heilborn; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Innate immunity; antimicrobial peptides; LL-37; epithelial cell; keratinocytes; proliferation; reepithelialization; wound healing; tissue repair; angiogenesis; tumor growth; vitamin D;

   Sammanfattning : Epithelia constitute the principal barriers separating the host and the potentially injurious environment, and defence of this interface is therefore essential. Antimicrobial peptides are key effector molecules of the innate immune system. LÄS MER