Sökning: "SHBG"

Visar resultat 1 - 5 av 30 avhandlingar innehållade ordet SHBG.

1. 1. Studies of hyperandrogenicity and the metabolic syndrome in premenopausal women

   Författare :Fariba Baghaei; Göteborgs universitet; []
   Nyckelord :androgens; SHBG; HPA axis; abdominal obesity; insulin; HDL; metabolic syndrome; ovarian volume; PCOS; polymorphism; genetics; androgen receptor; estrogen receptor; aromatase;

   Sammanfattning : An androgenic sex hormone profile appears to be a typical feature of the metabolic syndrome (MetS) and a powerful risk factor for the development of type 2 diabetes in women. The causes of relative hyperandrogenicity (HA) are not clearly defined. LÄS MER

3. 2. Protein Interactions Involving the Laminin G-type Domains of Vitamin K-dependent Protein S

   Författare :Petra Evenäs; Malmö Klinisk kemi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Klinisk kemi; Clinical chemistry; tyrosine phosphorylation.; Sky receptor; SHBG-like region; protein S; G domain; Gas6; Activated protein C; C4b-binding protein; Proteins; enzymology; Proteiner; enzymologi;

   Sammanfattning : The studies described in this thesis focus on the involvement of the two laminin G-type domains of vitamin K-dependent protein S in various biological contexts. The G-type domains are located in the C-terminal sex-hormone-binding globulin (SHBG)-like region. LÄS MER

4. 3. Molecular mechanisms of estrogen and antiestrogen action

   Författare :Tomas Barkhem; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Estrogen receptor; SHBG; tamoxifen; raloxifene; pS2; p1 60 coactivator; SRC-1; TIF-2;

   Sammanfattning : Estrogen is a key regulatory hormone that affects numerous physiological processes. The estrogen receptors (ER), ER alpha and ER beta, play a central role in mediating the effects of both estrogens and antiestrogens. Estrogen signaling has proven to be multifaceted and the precise mechanism of action remains in many cases elusive. LÄS MER

5. 4. Hormones and breast cancer : aspects on receptor expression and metabolism

   Författare :Lars Löfgren; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Breast cancer; fine needle aspiration biopsy; tamoxifen; megestrol acetate; SHBG; sex steroid hormone receptors; Syndecan-1;

   Sammanfattning : Breast cancer is the most common malignancy among women in the western world. Sex steroid hormones are implied as risk factors but endocrine regimens are also used in the therapy of breast cancer. Current knowledge about the endocrine and metabolic effects of different treatments is incomplete. LÄS MER

7. 5. Effects of combined oral contraceptives on hemostasis and biochemical risk indicators for venous thromboembolism and atherothrombosis

   Författare :Marianne van Rooijen; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Combined oral contraceptives; emergency contraception; menstrual cycle; ethinylestradiol; levonorgestrel; desogestrel; lipoproteins; hemostasis; risk indicators; APC resistance; SHBG;

   Sammanfattning : Combined oral contraceptives (COCs) are one of the most common contraceptive methods in the world. Already a few years after their introduction, in the early 1960s, case reports were published showing associations between use of COCs and venous and arterial thromboembolism. LÄS MER