Sökning: "peptide conjugates"

Visar resultat 1 - 5 av 33 avhandlingar innehållade orden peptide conjugates.

1. 1. Peptide Conjugates as Useful Molecular Tools

   Författare :Adam T. Ślósarczyk; Lars Baltzer; Knud J. Jensen; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; peptide conjugates; designed peptides; polypeptides; molecular recognition; linker; linking technology; bioconjugation; conjugation; conjugates; Kemi; Chemistry; Chemistry with specialization in Bioorganic Chemistry; Kemi med inriktning mot bioorganisk kemi;

   Sammanfattning : The conjugation of a small organic molecule to synthetic polypeptides from a designed set has been shown to give rise to binders with high affinity and selectivity for the phosphorylated model proteins α-casein and β-casein but not for ovoalbumin. The small organic molecule that was used for this purpose is comprised of two di-(2-picolyl)amine groups assembled on a dimethylphenyl scaffold, and is capable of complexing two Zn2+ ions to form chelates that bind the phosphate ion. LÄS MER

3. 2. Design, Synthesis and Characterization of Small Molecule Inhibitors and Small Molecule : Peptide Conjugates as Protein Actors

   Författare :Jonas Nilsson; Lars Baltzer; Ingemar Kvarnström; Thomas Olsson; Linköpings universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Synthetic receptor; Peptide inhibitor conjugate; Peptide protein surface interactions; General Lead Discovery Library; Combinatorial Chemistry; Solid Phase Chemistry; Targeted Library; Thrombin inhibitor; Fluorescence; Surface Plasmon Resonance; Organic chemistry; Organisk kemi;

   Sammanfattning : This thesis describes different aspects of protein interactions. Initially the function of peptides and their conjugates with small molecule inhibitors on the surface of Human Carbonic Anhydrase isoenzyme II (HCAII) is evaluated. LÄS MER

4. 3. Development of Peptide Binders : Applied to Human CRP, Carbonic Anhydrase (II, IX) and Lysine Demethylase 1

   Författare :Jie Yang; Jan Kihlberg; Morten Grötli; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; polypeptide conjugates; molecular recognition; peptide cyclization; protein targets;

   Sammanfattning : In this thesis, a polypeptide binder concept is illustrated. By conjugation to a set of sixteen polypeptides, a small binding molecule can evolve into a polypeptide binder with increased affinity and selectivity. LÄS MER

5. 4. Polypeptide Conjugates as High-affinity Binders for Proteins

   Författare :Lotta Tollstoy Tegler; Lars Baltzer; Amelie Eriksson Karlström; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Protein recognition; polypeptide conjugates; peptide; molecular interactions; C-reactive protein; Acetylcholine esterase; Human Carboinc anhydrase; Chemistry; Kemi; organisk kemi; Organic Chemistry;

   Sammanfattning : A novel concept for protein recognition has been developed. The recognition unit is a hybrid molecule obtained by conjugation of a small organic molecule to a synthetic polypeptide selected from a 16-membered set of 42 amino acid residue sequences. The sequences are unordered and have no prior relation to the target proteins. LÄS MER

7. 5. Cell-penetrating peptides, novel synthetic nucleic acids, and regulation of gene function : Reconnaissance for designing functional conjugates

   Författare :Peter Guterstam; Ülo Langel; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell-penetrating peptide; nucleic acids; alternative splicing; mismatch discrimination; Neurochemistry; Neurokemi;

   Sammanfattning : Our genome operates by sending instructions, conveyed by mRNA, for the manufacture of proteins from chromosomal DNA in the nucleus of the cell to the protein synthesizing machinery in the cytoplasm. Alternative splicing is a natural process in which a single gene can encode multiple related proteins. LÄS MER