Sökning: "opioid receptors"

Visar resultat 21 - 25 av 50 avhandlingar innehållade orden opioid receptors.

1. 21. DARPP-32 in the striatum : multiple regulation and physiological role

   Författare :Maria Lindskog; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :DARPP-32; striatum; adenosine A 2A receptors; dopamine D; receptors; dopamine D 2 receptors; opioid receptors; cAMP; protein phosphorylation; behaviour;

   Sammanfattning : Protein phosphorylation is an important mechanism involved in intracellular signal transduction. The activity of many proteins is affected by their state of phosphorylation, which in turn is determined by the combined activities of protein kinases and protein phosphatases. LÄS MER

3. 22. Interactions between the opioid and serotonin systems in chronic pain : quantitative live cell study by fluorescence cross-correlation spectroscopy (FCCS)

   Författare :Vlad Radoi; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Chronic pain is a major health issue worldwide. It enacts considerable suffering on the affected individuals and significantly increases the societal burden, as it is the most common reason why individuals seek sick leave and ask for medical help. LÄS MER

4. 23. The analgesic mechanisms of buprenorphine

   Författare :Poli Francois Kouya; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Buprenorphine; morphine; cross-tolerance; g- opioid receptors; inbred mice.;

   Sammanfattning : Buprenorphine, a derivative of thebaine, is a semi-synthetic opiate and a partial p-opioid receptor agonist. Buprenorphine is also a weak kappa-opioid receptor antagonist. Buprenorphine is used clinically as an analgesic and for maintenance therapy of opiate-dependent subjects because it produces limited withdrawal symptoms. LÄS MER

5. 24. Central pain after spinal cord injury : experimental studies with special emphasis on pharmacological treatment

   Författare :Wei Yu; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :allodynia; central pain; ischemia; spinal cord injury; intrathecal; opioid; opioid receptors; selective opioid agonists; selective opioid antagonists; tolerance; dependence; clonidine; bovine chromaffin cells; encapsulation; resiniferatoxin;

   Sammanfattning : Injuries and dysfunctions of the central nervous system can cause central pain which, according to clinical experience, is often refractory to conventional treatments. The present thesis consists of experimental studies on the mechanisms and treatments of central pain using a well-established animal model of central pain after spinal cord injury. LÄS MER

7. 25. Migration of molecules in the brain : focus on the extracellular space and the cerebrospinal fluid

   Författare :Malin Höistad; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Volume transmission; rat; diffusion; striatum; dual-probe microdialysis; delivery; recovery; clearance; uptake; dopamine; metabolism; radiotracer; mannitol; cisterna magna; opioids; peptides; betaendorphin; mu-opioid receptors; mismatch; TH; DBH; immunohistochemistry; fear.;

   Sammanfattning : Three different molecules and three different experimental models were used to study the migration of molecules in the rat brain: a neurotransmitter- dopamine, an extracellular market- mannitol, and a neuropeptide beta-endorphin. Two models in vivo were used to study the diffusion and migration of molecules: dual-probe rnicrodialysis in the striatum, and direct intrastriatal microinjections followed by cerebrospinal fluid sampling from the cisterna magna. LÄS MER