Sökning: "nucleus accumbens"

Visar resultat 1 - 5 av 51 avhandlingar innehållade orden nucleus accumbens.

  1. 1. Motion and Emotion Functional In Vivo Analyses of the Mouse Basal Ganglia

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Emma Arvidsson; Uppsala universitet.; [2014]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dopamine; Basal Ganglia; Reward System; In Vivo Chronoamperometry; Optogenetics; Deep Brain Stimulation; Parkinson’s Disease; Addiction; Glutamate; Vesicular Glutamate Transporter; VGLUT2; Sex; Age; Subthalamic Nucleus; Striatum; Nucleus Accumbens; Ventral Tegmental Area;

    Sammanfattning : A major challenge in the field of neuroscience is to link behavior with specific neuronal circuitries and cellular events. One way of facing this challenge is to identify unique cellular markers and thus have the ability to, through various mouse genetics tools, mimic, manipulate and control various aspects of neuronal activity to decipher their correlation to behavior. LÄS MER

  2. 2. Nicotine sensitization and the effects of extended withdrawal - behavioral, neurochemical and electrophysiological studies in the rat

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Julia Morud Lekholm; Göteborgs universitet.; Gothenburg University.; [2016]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Abstinence; Dopamine; Elevated plus-maze; GABA; Inhibitory control; Nicotine; Nucleus accumbens; Sensitization;

    Sammanfattning : Tobacco use is one of the primary factors for global burden of disease and often results in life-long nicotine addiction, only a small percentage users are able to maintain cessation. The life-long addiction together with a high relapse risk might be connected to drug-induced altered neural circuits. LÄS MER

  3. 3. Glycine receptors in the central nervous system - development, distribution and relation to actions of alcohol

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Susanne Jonsson; Göteborgs universitet.; Gothenburg University.; [2012]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glycine receptor; nucleus accumbens; alcohol; gene expression; dopamine;

    Sammanfattning : The widespread consumption of alcohol and the great socioeconomic impact of alcohol abuse and addiction have contributed to the extensive investigations of this substance. Despite great efforts there is still uncertainty concerning how alcohol exerts its effects and the mechanisms behind the transition from consumption to addiction. LÄS MER

  4. 4. Preclinical investigations of GlyT-1 inhibition as a new concept for treatment of alcohol dependence

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Helga Lidö Höifödt; Göteborgs universitet.; Gothenburg University.; [2011]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Psykiatri experimentell ; Neurofarmakologi; alcohol; dependence; dopamine; GlyT-1 inhibition; nucleus accumbens; reward;

    Sammanfattning : Alcohol addiction and abuse is a main contributor to the global burden of disease and is a high public health priority. Alcohol addiction is a chronically relapsing neurobiological disorder affecting multiple neurotransmitter systems. LÄS MER

  5. 5. Conditional and non-conditional reward-related responses to alcohol. Nicotinic mechanisms

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Elin Löf; Göteborgs universitet.; Gothenburg University.; [2006]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ethanol; nicotine; ventral tegmental area; nucleus accumbens; dopamine; nicotinic acetylcholine receptor; gamma-amino-butyric acid receptor A; conditioned reinforcement; in vivo microdialysis; rat;

    Sammanfattning : The mesolimbic dopamine system is believed to mediate the positive reinforcing and rewarding effects of addictive drugs by increasing dopamine levels in its terminal area, the nucleus accumbens (nAc). Nicotinic acetylcholine receptors (nAChRs) within this system appear important for the pharmacological actions of both alcohol and nicotine, which may explain the frequent co-abuse of these two drugs. LÄS MER