Sökning: "neuropathic"

Visar resultat 1 - 5 av 98 avhandlingar innehållade ordet neuropathic.

1. 1. Development of Substance P 1–7 Related Peptides and Peptidomimetics : Targeting Neuropathic Pain

   Författare :Anna Skogh; Anja Sandström; Christian Sköld; Rebecca Fransson; Philip Thompson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Substance P 1–7; Peptidomimetics; Solid-phase Peptide Synthesis SPPS ; Palladium catalysis; Carbonylation; Imidazole; Bioisostere; Neuropathic pain; Allodynia; Structure-activity relationships; Medicinal Chemistry; Läkemedelskemi;

   Sammanfattning : The neuropeptide substance P 1–7 (SP1–7, H-Arg1-Pro2-Lys3-Pro4-Gln5-Gln6-Phe7-OH) and its amidated analogue SP1–7 amide, have displayed intriguing effects in experimental models for neuropathic pain acting on a specific, yet unknown SP1–7 target. The aim of this thesis was to design and synthesise SP1–7 related peptides and peptidomimetics, to be used as research tools to study the SP1–7 system, and to serve as drug leads in the neuropathic pain area. LÄS MER

3. 2. Molecular Signatures of Neuropathic Pain : Revealing Pain-Related Signaling Processes in Spinal Cord Using Mass Spectrometric Methodologies

   Författare :Ping Sui; Jonas Bergquist; Konstantin Artemenko; Janne Lehtiö; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mass spectrometry; Spinal cord; Neuropathic pain; Quantitative proteomics; Imaging mass spectrometry; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry;

   Sammanfattning : In this thesis, the detection of global proteomics alteration and changes in neuropeptide distribution caused by neuropathic pain in rat spinal cord tissue was the main focus. Neuropathic pain (NP) is a major clinical syndrome caused by disease or dysfunction of the nervous system and often mediated by neuronal networks in the spinal cord. LÄS MER

4. 3. Neuropathic Pain; Quality of Life, Sensory Assessments and Pharmacological Treatments

   Författare :Ann Kvarnström; Torsten Gordh; Rolf Karlsten; Per Hansson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anaesthesiology and intensive care; neuropathic pain; Anestesiologi och intensivvård; Anaesthetics and intensive care; Anestesiologi och intensivvård;

   Sammanfattning : Neuropathic pain of central and peripheral origin presents a substantial clinical problem as it is often resistant to pharmacological treatment.The health related quality of life of 126 patients with peripheral neuropathic pain was studied, to provide a cross sectional description from this point of view. LÄS MER

5. 4. Dilemmas and consequences of chronic disease-lived experiences of coeliac disease and neuropathic pain

   Författare :Annette Sverker; Göteborgs universitet; []
   Nyckelord :Burden of dietary restriction; chronic disease; coeliac disease; critical - incident technique; dietary dilemmas; neuropathic pain; next of kin experiences; quality of life;

   Sammanfattning : Dilemmas and consequences of chronic disease-lived experiences of coeliac disease and neuropathic pain Akademisk avhandling som för avläggande av medicine doktorsexamen vid Sahlgrenska akademin vid Göteborgs Universitet kommer att offentligt försvaras i lokal Arvid Wallgrens Backe, Hus 2, 2118, Sahlgrenska Akademin, Göteborg. torsdagen den 27 september 2007, kl 13. LÄS MER

7. 5. Tetrodotoxin-resistant sodium channels in neuropathic pain

   Författare :Jenny Fjell Hjelmström; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :spinal sensory neurons; nociceptor; IB4; tetrodotoxin; sodium channels; SNS PN3; NaN SNS2; gene regulation; NGF; GDNF; in situ hybridization; immunofluorescence; sodium currents; neuropathic pain models; Taiep;

   Sammanfattning : Injury to the peripheral nervous system can cause neuropathic pain. Abnormal sodium channel activity has been implicated as a source of ectopic firing and changes in nociceptive threshold following nerve injury. LÄS MER