Sökning: "molecular crowding"
Visar resultat 1 - 5 av 16 avhandlingar innehållade orden molecular crowding.
1. Analysis of Binding Events and Diffusion in Living Cells
Sammanfattning : It is well known that diffusion is the main mode of transport in living cells, but the consequences of diffusion in a complex cellular environment are not generally appreciated. In this thesis, we have investigated several aspects of how diffusion properties influence the observability of cellular binding kinetics and how they can be used to obtain information about the environment of proteins and other molecules. LÄS MER
2. Folding and interaction studies of subunits in protein complexes
Sammanfattning : Proteins function as worker molecules in the cell and their natural environment is crowded. How they fold in a cell-like environment and how they recognize their interacting partners in such conditions, are questions that underlie the work of this thesis. LÄS MER
3. A scattering study of concentrated lens protein solutions and mixtures - Towards understanding the molecular origin of presbyopia
Sammanfattning : Healthy eye lenses are transparent and flexible, able to adapt shape in order to focus on far away and close-by objects. With age, however, this flexibility is lost, leading to a condition known as presbyopia. This vision disorder where close-by objects appear blurred commonly starts around the age of 40. LÄS MER
4. Protein stability and mobility in live cells : Revelation of the intracellular diffusive interaction organization mechanisms
Sammanfattning : Biochemical processes inside living cells take place in a confined and highly crowded environment. As such, macromolecular crowding, one of the most important physicochemical properties of cytoplasm, is an essential element of cell physiology. LÄS MER
5. Roles of intermolecular interactions in amyloid fibril formation mechanisms
Sammanfattning : Amyloid fibrils, a major pathological feature of several neurodegenerative disorders, are highly stable, insoluble aggregates of misfolded proteins. The formation of such aggregates involves a complex equilibrium between protein monomers, different on- and off-pathway transient oligomeric species, and amyloid fibrils. LÄS MER
