Sökning: "Golgi"
Visar resultat 1 - 5 av 109 avhandlingar innehållade ordet Golgi.
1. Functional characterization of the secretory pathway and the role of COPI vesicles
Sammanfattning : In the secretory pathway, proteins synthesized in the endoplasmatic reticulum move through the Golgi apparatus in a cis-to-trans direction and then sorts into different types of vesicles at the trans-Golgi network. How intracellular transport takes place has been the focus of cell biology research for a long time. LÄS MER
2. Analysis of Binding Events and Diffusion in Living Cells
Sammanfattning : It is well known that diffusion is the main mode of transport in living cells, but the consequences of diffusion in a complex cellular environment are not generally appreciated. In this thesis, we have investigated several aspects of how diffusion properties influence the observability of cellular binding kinetics and how they can be used to obtain information about the environment of proteins and other molecules. LÄS MER
3. Haptoglobin: Biosynthesis and Evolution
Sammanfattning : Haptoglobin (Hp) is a serum protein known for its ability to form a tight complex with hemoglobin (Hb) and thereby inhibiting the oxidative activity of Hb. Mammalian Hp is synthesized as a precursor (proHp) that undergoes proteolytic cleavage by a previously unidentified enzyme in the endoplasmic reticulum (ER). LÄS MER
4. Cellular design of heparan sulfate : The NDST enzymes and their regulation
Sammanfattning : Heparan sulfate proteoglycans are proteins with long, unbranched heparan sulfate (HS) polysaccharide chains attached to them. They are found on cell surfaces and in basement membranes where they exert their action by interacting with a wide range of enzymes and signaling molecules and are thereby involved in a range of various processes both during embryonic development and in adult physiology. LÄS MER
5. Localisation of Protein Kinase C in Apoptosis and Neurite Outgrowth
Sammanfattning : Protein kinase C (PKC) is a family of serine/threonine kinases, which are subgrouped into classical (a, bI, bII, g), novel (d, e, h, q) and atypical (z, i/l) isoforms. One major aim of this thesis work was to investigate if altered levels of PKC isoforms influence the apoptotic responses of malignant cell-lines. LÄS MER