Sökning: "Johan Elf"

Visar resultat 1 - 5 av 16 avhandlingar innehållade orden Johan Elf.

1. 1. Clinical probability assessment and biochemical markers in the diagnosis of deep vein thrombosis

   Författare :Johan Elf; Malmö Klinisk koagulationsmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Venous thrombosis; APC-PCI complex.; D-Dimer; Clinical probability; Diagnosis;

   Sammanfattning : The combination of pre-test clinical probability assessment and D-dimer test is now widely applied in the diagnostic process of DVT. The general objective of the present investigation was to validate these results in a Swedish routine emergency setting were the prevalence of the disease is high and were the clinical probability assessment was handled by many junior physicians. LÄS MER

3. 2. Intracellular Flows and Fluctuations

   Författare :Johan Elf; Måns Ehrenberg; Peter Wolynes; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; mesoscopic; reaction-diffusion; protein synthesis; amino acid; flow; fluctuations; Molekylärbiologi; Molecular biology; Molekylärbiologi; Molecular Biotechnology; Molekylär bioteknik;

   Sammanfattning : Mathematical models are now gaining in importance for descriptions of biological processes. In this thesis, such models have been used to identify and analyze principles that govern bacterial protein synthesis under amino acid limitation. LÄS MER

4. 3. Modelling Approaches to Molecular Systems Biology

   Författare :David Fange; Måns Ehrenberg; Johan Elf; Terence Hwa; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; stochastic reaction-diffuion kinetics; antibiotic drugs; efflux pumps; amino acid biosynthesis; Min-system; rRNA operon; transcription; Molecular biology; Molekylärbiologi; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

   Sammanfattning : Implementation and analysis of mathematical models can serve as a powerful tool in understanding how intracellular processes in bacteria affect the bacterial phenotype. In this thesis I have implemented and analysed models of a number of different parts of the bacterium E. coli in order to understand these types of connections. LÄS MER

5. 4. Bacterial DNA repair and molecular search

   Författare :Arvid H. Gynnå; Johan Elf; Stephen Kowalczykowski; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; DNA repair; DNA damage; homologous recombination; homologous repair; recombination; RecA; I-SceI; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

   Sammanfattning : Surveillance and repair of DNA damage is necessary in all kinds of life. Different types of DNA damage require different repair mechanisms, but these mechanisms are often similar in all domains of life. The most serious type of damage, double stranded DNA breaks, are for example repaired in conceptually similar ways in both bacteria and eukaryotes. LÄS MER

7. 5. lac of Time : Transcription Factor Kinetics in Living Cells

   Författare :Petter Hammar; Johan Elf; Antoine van Oijen; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; gene regulation; transcription factor; lac operon; facilitated diffusion; single molecule imaging; Molecular Biotechnology; Molekylär bioteknik;

   Sammanfattning : Gene regulation mediated by transcription factors (TFs) is essential for all organisms. The functionality of TFs can largely be described by the fraction of time they occupy their regulatory binding sites on the chromosome. DNA-binding proteins have been shown to find their targets through facilitated diffusion in vitro. LÄS MER