Sökning: "lamivudine"
Visar resultat 1 - 5 av 12 avhandlingar innehållade ordet lamivudine.
1. Drug Analysis : Bioanalytical Method Development and Validation
Sammanfattning : This thesis describes bioanalytical methods for drug determination in biological matrixes, with drugs in focus used against diseases largely affecting low-income countries. Solid-phase extraction is used for sample cleanup, and processed samples are analyzed by liquid chromatography. LÄS MER
2. Development and Validation of Bioanalytical Methods : Application to Melatonin and Selected Anti-Infective Drugs
Sammanfattning : This thesis describes bioanalytical methods for measuring melatonin and some anti-infective drugs in biological fluids. Solid-phase extraction (SPE) or protein precipitation was used for enrichment and purification of the analytes and Liquid Chromatography (LC) was used to analyze the samples. LÄS MER
3. Real-time PCR studies of genotypes, mutations and replication of hepatitis B virus
Sammanfattning : Infection with hepatitis B virus (HBV) is an important cause of liver disease and affects 350 million people worldwide, causing 600,000 deaths/year. Treatment includes interferon and nucleoside analogues (NAs) such as lamivudine, entecavir, and tenofovir. LÄS MER
4. Resistance to antiviral drugs in HIV and HBV
Sammanfattning : Development of resistance to antiviral drugs is a major problem in treatment of several viral infections including human immunodeficiency type 1 (HIV-1) and hepatitis B virus (HBV). Resistance may be the primary reason for treatment failure, but may also develop secondary to problems with adherence or pharmacokinetics. LÄS MER
5. Resolution of Dynamic Systems: Applications in Asymmetric Synthesis and Materials Science
Sammanfattning : This thesis is built on the concepts of constitutional dynamic chemistry and dynamic kinetic resolution, where reversible covalent reactions are used to generate dynamics and kinetically controlled reactions are employed for resolution. The thesis is divided into two parts:The first section focuses on the study of dynamic systemic resolution, a concept derived from constitutional dynamic chemistry. LÄS MER