Sökning: "antiretroviral drugs"

Visar resultat 1 - 5 av 48 avhandlingar innehållade orden antiretroviral drugs.

  1. 1. Development and Validation of Bioanalytical Methods : Application to Melatonin and Selected Anti-Infective Drugs

    Författare :Susanne Römsing; Yngve Bergqvist; Åsa Emmer; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; african trypanosomiasis; melatonin; malaria; antiretroviral drugs; lumefantrine; tafenoquine; lamivudine; nevirapine; zidovudine; sampling paper; dried blood spots; capillary blood; antimalarial drugs; solid-phase extraction; liquid chromatography; Chemistry; Kemi; Analytical Chemistry; Analytisk kemi;

    Sammanfattning : This thesis describes bioanalytical methods for measuring melatonin and some anti-infective drugs in biological fluids. Solid-phase extraction (SPE) or protein precipitation was used for enrichment and purification of the analytes and Liquid Chromatography (LC) was used to analyze the samples. LÄS MER

  3. 2. Short modified peptides and their metabolites inhibit HIV replication

    Författare :Elin Andersson; Göteborgs universitet; []
    Nyckelord :HIV-1; AIDS; GPG-NH2; G-NH2; antiretroviral drugs; Dipeptidyl peptidase IV; CD26; prodrug;

    Sammanfattning : Several drugs inhibiting the replication of HIV-1, the causative agent of AIDS, are available today. However, HIV-1 treatment is hampered by side effects, poor adherence and development of resistance. LÄS MER

  4. 3. Antiretroviral treatment of HIV-1 in the central nervous system

    Författare :Aylin Yilmaz; Göteborgs universitet; []
    Nyckelord :HIV-1; cerebrospinal fluid; antiretroviral treatment; lopinavir; saquinavir; nelfinavir; neopterin; beta-2-microglobulin; HIV-1 RNA; IgG index; blood-brain barrier; albumin ratio; ultra-ultra sensitive PCR;

    Sammanfattning : HIV-1 invades the central nervous system (CNS) early in the infectious course. It establishes a chronic progressive infection, and triggers an intrathecal immune response. If left untreated, a majority of patients will develop neurological complications, caused by opportunistic pathogens or HIV-1 itself. LÄS MER

  5. 4. The battleground of two Infections and a cancer: Human Papilloma Virus, premalignant lesions of the cervix and their interaction with Human Immunodeficiency Virus in southwestern Nigeria

    Författare :Oliver Ezechi; Socialmedicin och global hälsa; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antiretroviral drugs; Human papilloma virus; cervical cancer; HIV AIDS; pre-cancerous lesions; Nigeria;

    Sammanfattning : Background: The highest numbers of HIV-infected women are in sub- Saharan Africa, where the natural progression of HIV disease in the absence of treatment results in death before the onset of invasive cervical cancer. With improved access to treatment, several studies outside West Africa demonstrated an increased risk of pre-invasive cervical lesions among HIV-infected women and the positive impact of treatment on the outcome. LÄS MER

  7. 5. Pharmacometric Models to Improve Treatment of Tuberculosis

    Författare :Elin M Svensson; Mats O Karlsson; Maria C Kjellsson; Ulrika S H Simonsson; N. L’Ntshotsholé (Shasha) Jumbe; Uppsala universitet; []
    Nyckelord :pharmacokinetics; pharmacodynamics; population approach; nonlinear mixed-effects models; multidrug-resistant tuberculosis; bedaquiline; antiretroviral; drug-drug interactions; time-to-event; albumin; Klinisk farmakologi; Clinical Pharmacology;

    Sammanfattning : Tuberculosis (TB) is the world’s most deadly infectious disease and causes enormous public health problems. The comorbidity with HIV and the rise of multidrug-resistant TB strains impede successful therapy through drug-drug interactions and the lack of efficient second-line treatments. LÄS MER