Sökning: "lamivudine resistance"

Visar resultat 1 - 5 av 7 avhandlingar innehållade orden lamivudine resistance.

  1. 1. Real-time PCR studies of genotypes, mutations and replication of hepatitis B virus

    Författare :Sebastian Malmström; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hepatitis B virus; real-time PCR; lamivudine resistance; genotypes; replication;

    Sammanfattning : Infection with hepatitis B virus (HBV) is an important cause of liver disease and affects 350 million people worldwide, causing 600,000 deaths/year. Treatment includes interferon and nucleoside analogues (NAs) such as lamivudine, entecavir, and tenofovir. LÄS MER

  3. 2. Resistance to antiviral drugs in HIV and HBV

    Författare :Anna Lindström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HIV-1; HBV; drug-resistance; Sanger sequencing; pyrosequencing;

    Sammanfattning : Development of resistance to antiviral drugs is a major problem in treatment of several viral infections including human immunodeficiency type 1 (HIV-1) and hepatitis B virus (HBV). Resistance may be the primary reason for treatment failure, but may also develop secondary to problems with adherence or pharmacokinetics. LÄS MER

  4. 3. Studies of drug resistance in minor HIV quasispecies

    Författare :Halime Ekici; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The main objective was to study drug resistance mutations (DRM) in the HIV-1 reverse transcriptase (RT) gene of minor HIV-1 quasispecies, not detectable with standard techniques. Sensitive allele-specific PCR (AS- PCR) and next-generation sequencing (NGS) were developed to study resistance to drugs of relevance in low- and middle-income countries (LMIC); the nucleoside analogue RT inhibitor (NRTI) lamivudine (3TC) and the non-nucleoside RT inhibitors (NNRTIs) efavirenz (EFV) and nevirapine (NVP). LÄS MER

  5. 4. Paediatric HIV infection in Maputo, Mozambique : horizontal transmission, treatment outcomes and drug resistance

    Författare :Paula Vaz; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : This thesis describes observational studies performed at the main reference centre for paediatric HIV care and management in Mozambique, which is one of the countries most strongly affected by the AIDS pandemic. These studies focused on horizontal transmission, treatment outcomes and paediatric antiretroviral drug resistance in a cohort of HIV-1-infected children. LÄS MER

  7. 5. In vivo and in vitro models for determination of antiviral activity and resistance

    Författare :Ewa Ljungdahl Ståhle; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The AIDS epidemic has been the driving force for the discovery of substances that inhibit the replication of human immunodeficiency virus (HIV). Much interest has earlier focused on a single gene product central to the life cycle of HIV and to all other retroviruses: the reverse transcriptase (RT), the enzyme responsible for synthesis of DNA from viral RNA. LÄS MER