Sökning: "intestinal parasite"

Visar resultat 1 - 5 av 23 avhandlingar innehållade orden intestinal parasite.

1. 1. Studies of Giardia-host interactions: role of cysteine-rich surface proteins

   Författare :Dimitra Peirasmaki; Staffan Svärd; Steven Singer; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Giardia; intestinal parasite; parasite infection; host-parasite interaction; virulence factors; HCMPs; cysteine-rich proteins; secretome; proteome;

   Sammanfattning : Giardia intestinalis is a eukaryotic parasite that colonizes the small intestine of humans and animals causing the diarrheal disease known as giardiasis. This parasite is not invasive and does not internalize into host cells but it rather attaches to the brush border surface of the small intestine disrupting the epithelial barrier. LÄS MER

3. 2. Genetic subtypes in unicellular intestinal parasites with special focus on Blastocystis

   Författare :Joakim Forsell; Birgitta Evengård; Margareta Granlund; Tom van Gool; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Intestinal parasites; Blastocystis; Entamoeba; Giardia; molecular detection; PCR; subtype; intestinal microbiota; Sweden; Zanzibar; Clinical Bacteriology; klinisk bakteriologi;

   Sammanfattning : The development of molecular tools for detection and typing of unicellular intestinal parasites has revealed genetic diversities in species that were previously considered as distinct entities. Of great importance is the genetic distinction found between the pathogenic Entamoeba histolytica and the non-pathogenic Entamoeba dispar, two morphologically indistinguishable species. LÄS MER

4. 3. The interplay between Giardia intestinalis and host intestinal epithelial cells : A tale of immune activation and suppression

   Författare :Jana Grüttner; Staffan Svärd; Mikael E. Sellin; Steven Singer; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Giardia; diarrhea; RNAseq; proteomics; small intestinal epithelial cells; enteroids; organoids; protozoan; differentiation; immune response; host-parasite interaction; swimming; Biologi med inriktning mot mikrobiologi; Biology with specialization in Microbiology;

   Sammanfattning : Giardia intestinalis is a non-invasive, protozoan parasite causing the diarrheal disease giardiasis in a variety of mammals, including humans. The parasite has two main life cycle stages; disease-causing trophozoites and infectious cysts. Trophozoites colonize the host’s upper small intestine by attaching to intestinal epithelial cells (IECs). G. LÄS MER

5. 4. Comparative Cell Biology in Diplomonads

   Författare :Elin Einarsson; Staffan Svärd; Scott Dawson; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Giardia intestinalis; Spironucleus salmonicida; intestinal parasite; hydrogenosome; encystation; gene regulation; transfection; diplomonad; antigenic variation; annexin;

   Sammanfattning : The diplomonads are a diverse group of eukaryotic flagellates found in microaerophilic and anaerobic environments. The most studied diplomonad is the intestinal parasite Giardia intestinalis, which infects a variety of mammals and cause diarrheal disease. LÄS MER

7. 5. Comparative Genomics in Diplomonads : Lifestyle Variations Revealed at Genetic Level

   Författare :Feifei Xu; Jan O. Andersson; Staffan G. Svärd; Matt Berriman; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; comparative genomics; Giardia intestinalis; Spironucleus salmonicida; Trepomonas; diplomonad; intestinal parasite; free-living; sexual recombination; hydrogenosome; horizontal gene transfer; Biologi med inriktning mot molekylär evolution; Biology with specialization in Molecular Evolution;

   Sammanfattning : As sequencing technologies advance genome studies are becoming a basic tool for studying an organism, and with more genomes available comparative genomics is maturing into a powerful tool for biological research. This thesis demonstrates the strength of a comparative genomics approach on a group of understudied eukaryotes, the diplomonads. LÄS MER