Sökning: "in-silico analysis"

Visar resultat 1 - 5 av 74 avhandlingar innehållade orden in-silico analysis.

  1. 1. On striatum in silico

    Författare :Johanna Frost Nylén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The basal ganglia are a collection of subcortical nuclei involved in movement and action selection. The striatum is the main input nucleus with extensive projections from the cortex and thalamus, and dopaminergic projections from SNc and VTA. LÄS MER

  3. 2. In silico tools in risk assessment : of industrial chemicals in general and non-dioxin-like PCBs in particular

    Författare :Mia Stenberg; Patrik Andersson; Miriam Jacobs; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chemometrics; industrial chemicals; in silico tools; molecular descriptors; non-dioxin-like PCBs; partial least-squares PLS ; principal component analysis PCA ; quantitative structure-activity relationship QSAR ; REACH; risk assessment RA ; statistical molecular design; structure-activity relationship SAR ;

    Sammanfattning : Industrial chemicals in European Union produced or imported in volumes above 1 tonne annually, necessitate a registration within REACH. A common problem, concerning these chemicals, is deficient information and lack of data for assessing the hazards posed to human health and the environment. LÄS MER

  4. 3. Improving alternatives assessment of plastic additives : exploring in silico tools to identify less hazardous flame retardants

    Författare :Ziye Zheng; Patrik L. Andersson; Hans Peter Arp; Gregory Peters; Gerrit Schüürmann; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Chemical alternatives assessment; plastic additives; flame retardants; hazard; emission; in silico; modeling; quantitative structure-activity relationship QSAR ; multi-criteria decision analysis MCDA ; environmental science; miljövetenskap; organisk kemi; Organic Chemistry; ekotoxikologi; Ecotoxicology; Toxicology; toxikologi;

    Sammanfattning : Alternatives assessment is applied for replacing hazardous chemicals with viable, safer substitutes. High quality experimental hazard data, however, are usually unavailable for this purpose, and obtaining in silico data is the only approach to fill in data gaps. LÄS MER

  5. 4. In silico prediction of CIS-regulatory elements

    Författare :Albin Sandelin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Transcriptional regulation; transcription factor binding sites; phylogenetic footprinting; pattern finding; pattern comparison;

    Sammanfattning : As one of the most fundamental processes for all life forms, transcriptional regulation remains an intriguing and challenging subject for biomedical research. Experimental efforts towards understanding the regulation of genes is laborious and expensive, but can be substantially accelerated with the use of computational predictions. LÄS MER

  7. 5. In silico Studies of Early Eukaryotic Evolution

    Författare :Björn Canbäck; Martin Embley; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Molekylärbiologi; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : A question of great interest in evolutionary biology is how and why the eukaryotic cell evolved. Several hypotheses have been proposed, ranging from an early emergence of a primitive eukaryotic cell, to various fusion models like the hydrogen hypothesis. Within this context, relevant bacterial gene families and genomes are examined in this thesis. LÄS MER