Sökning: "global methylation"

Visar resultat 11 - 15 av 57 avhandlingar innehållade orden global methylation.

  1. 11. DNA methylation and 5-azacytidine in myelodysplastic syndromes : pharmacodynamic, mechanistic and clinical studies

    Författare :Rasheed Khan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Global DNA Methylation; Gene-specific methylation; Myelodysplastic syndromes; 5-azacytidine.;

    Sammanfattning : Promoter DNA hypermethylation and hence silencing of e.g. tumour suppressor genes is considered to be an important step in carcinogenesis and has been associated with poor outcome in patients with myelodysplastic syndromes (MDS). LÄS MER

  3. 12. Local and global contaminants in Swedish waters : studies on PCBs, DDTs, 4,5,6-trichloroguaiacol and their transformation products in fish and sediments

    Författare :Maria Söderström; Åke Bergman; Bert van Bavel; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; PCB; DDT; HCB; trichloroguaiacol; transformation products; dimerisation; bromination; environmental pollutants; eutrophication; lakes; fresh water; baltic sea; monitoring; sediments; fish; phytoplankton; PCB; DDT; HCB; triklorguajakol; omvandlingsprodukter; dimerisering; bromering; miljöföroreningar; eutrofiering; sjöar; sötvatten; östersjön; miljöövervakning; sediment; fisk; fytoplankton; miljökemi; Environmental Chemistry;

    Sammanfattning : This thesis is focused on studies on the environmental fate and methodological improvements for determination of the global contaminants, PCBs and DDTs, and locally discharged phenolics, e.g. 4,5,6-trichloroguaiacol (4,5,6-TCG), and their transformation products. LÄS MER

  4. 13. Array-based Characterization of Chronic Lymphocytic Leukemia : - with Focus on Subsets Carrying Stereotyped B-cell Receptors

    Författare :Millaray Marincevic; Richard Rosenquist; Andreas Rosenwald; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chronic lymphocytic leukemia; array-based characterization; stereotyped B-cell receptors; subsets; antigens; SNP array; gene expression array; methylation array; Clinical genetics; Klinisk genetik; Clinical Genetics; Klinisk genetik;

    Sammanfattning : In chronic lymphocytic leukemia (CLL), the presence of multiple subsets expressing ‘stereotyped’ B-cell receptors (BCRs) has implicated antigen(s) in leukemogenesis. These stereotyped subsets display similar immunoglobulin (IG) gene usage, almost identical complementarity determining region 3’s and may share clinical features. LÄS MER

  5. 14. DNA methylation and gene expression patterns in adrenal medullary tumors

    Författare :Nimrod G B Kiss; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Pheochromocytomas and abdominal paragangliomas are neuroendocrine tumors of the autonomous nervous system, arising in adrenal medulla and sympathetic ganglia throughout the abdomen. These tumors originate from catecholamine-producing chromaffin cells. Neuroblastomas are common childhood tumors in the adrenal medulla and abdominal ganglia. LÄS MER

  7. 15. Genome-wide epigenetic profiling of B cell leukemia and lymphoma

    Författare :Mohammad Hamdy Abdelrazak Morsy; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CLL; PRC2; EZH2; Epigenetics; CpG islands; DNA methylation; ChIP-seq; RNA-seq;

    Sammanfattning : Epigenetic modifications, at the level of DNA methylation and post-translational modifications of histone tails cooperatively function in the organization of the genome, and thereby establish the gene expression profiles, phenotypes, and cellular fates. In this work, we investigated the aberrant epigenome in chronic lymphocytic leukemia (CLL) which is one of the most frequent lymphoid malignancies in the west including the Nordic countries. LÄS MER