Sökning: "genomes"

Visar resultat 6 - 10 av 393 avhandlingar innehållade ordet genomes.

1. 6. Sequencing of genes and genomes

   Författare :Fredrik Sterky; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; DNA sequencing; genome analysis; expressed sequence tag; expression analysis; complementary DNA; biotin-capture; solid-phase technology; automation; poplar; Bioengineering; Bioteknik;

   Sammanfattning : .... LÄS MER

3. 7. Microbial life deep underground : From anaerobic cultures to reconstructed genomes

   Författare :George Westmeijer; Mark Dopson; Hans Røy; Linnéuniversitetet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Continental deep biosphere; microbial ecology; anaerobic enrichment cultures; Candidatus Desulforudis audaxviator; Thiobacillus denitrificans; flow-cells; Mikrobiologi; Microbiology; Ecology; Ekologi;

   Sammanfattning : The deep biosphere refers to the vast ecosystem of life beneath the Earth’s surface, residing in the fractured bedrock and pores of rocks, largely isolated from solar energy. These fractures enclose an important reservoir of groundwater that contains microorganisms active in processes such as the uptake of inorganic carbon, sulfur cycling, or the degradation of organic matter. LÄS MER

4. 8. Somatic Mutations in Breast Cancer Genomes : Discovery and Validation of Breast Cancer Genes

   Författare :Xiang Jiao; Tobias Sjöblom; Anne-Lise Børresen-Dale; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; breast cancer; cancer gene; pathway; somatic mutation; structural alteration; sequencing; whole genome amplification; Genetics; Genetik; Medical Genetics; Medicinsk genetik;

   Sammanfattning : Breast cancer is the most common cancer in women worldwide. However, the genetic alterations that lead to breast cancer are not fully understood. This thesis aims to identify novel genes of potential mechanistic, diagnostic or therapeutic interest in breast cancers by mutational analysis and whole-genome sequencing. LÄS MER

5. 9. Nucleotide Substitution Patterns in Vertebrate Genomes

   Författare :Carina Farah Mugal; Hans Ellegren; Ziheng Yang; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; nucleotide substitutions; mutation rate variation; strand asymmetries; CpG effect; GC-biased gene conversion; codon evolution; Biologi med inriktning mot molekylär evolution; Biology with specialization in Molecular Evolution;

   Sammanfattning : The rates and patterns at which nucleotide substitutions occur vary significantly across the genome sequence of vertebrates. A prominent example is the difference in the rate of evolution of functional sequences versus nonfunctional (neutrally evolving) sequences, which is explained by the influence of natural selection on functional sequences. LÄS MER

7. 10. Human demographic history : Insights on the human past based on genomes from Southern through Central Africa

   Författare :Gwenna Breton; Mattias Jakobsson; Carina Schlebusch; Per Sjödin; Paul Verdu; David Comas; Uppsala universitet; []
   Nyckelord :high-coverage genomes; Sub-Saharan Africa; demography; genetic admixture; population genetics; human evolutionary genetics; Khoe-San; rainforest hunter-gatherers; Biology with Specialisation in Human Evolution and Genetics; Biologi med inriktning mot människans evolution och genetik;

   Sammanfattning : Evidence from paleontology, archaeology and population genetics support that modern humans originated in Africa. While the out-of-Africa event and subsequent colonization of all continents are well documented, human history in Africa at that time and before is less studied. LÄS MER