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Visar resultat 1 - 5 av 7 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Gene expression during hard tissue formation

   Författare :Catharina Ellerström; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :bone; dentin; mRNA; fibrillar collagens; osteonectin; fibronectin; development; rat;

   Sammanfattning : The purpose of this thesis was to study the formation of the extracellular matrix (ECM) of bone and dentin during development. Molecular techniques, such as in situ hybridization and RT-PCR, were used to investigate the occurrence of specific gene products in formative cells. LÄS MER

3. 2. Cartilage Oligomeric Matrix Protein (COMP). Functions in collagen binding and assembly

   Författare :Krisztina Rosenberg; Institutionen för experimentell medicinsk vetenskap; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Clinical biology; Klinisk biologi;

   Sammanfattning : Connective tissues contain a prominent extracellular matrix that provides mechanical and physical properties. This extracellular matrix contains as a major constituent a network of collagen fibres. These are composed of collagen fibrils, which in turn are assembled from many collagen molecules aligned parallel to each other. Several proteins, e. LÄS MER

4. 3. Collagen VI - Molecular Assembly and Interactions

   Författare :Charlotte Wiberg; Institutionen för experimentell medicinsk vetenskap; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Clinical biology; extracellular matrix; glycosaminoglycan; proteoglycan; collagen; biglycan; decorin; Klinisk biologi;

   Sammanfattning : The extracellular matrix plays an integral role in tissue remodeling and development and it defines the different mechanical properties of a variety of connective tissues. Its complexity in composition and the details in organization has only been partly elucidated. LÄS MER

5. 4. Structure and Interactions of the Extracellular Matrix Protein PRELP

   Författare :Eva Bengtsson; Institutionen för experimentell medicinsk vetenskap; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; reumatologi; muskelsystem; Skelett; extracellular matrix; PRELP; heparin; heparan sulfate; perlecan; collagen; cell-binding; Skeleton; rheumatology locomotion; muscle system; Biochemistry; Metabolism; Biokemi;

   Sammanfattning : This thesis describes the structure and interactions of a novel extracellular matrix protein - PRELP (proline arginine-rich end leucine-rich repeat protein). The amino acid sequence of PRELP showed that it belonged to the leucine-rich repeat (LRR) protein family in connective tissues. LÄS MER

7. 5. Molecular and microscopical analysis of pathogenic streptococci - studies on surface proteins interacting with human cells and extracellular matrix

   Författare :Marta Bober; Infektionsmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Streptococcus pyogenes; streptococcal leucine rich repeat protein; M protein; collagen; keratinocytes;

   Sammanfattning : Association to specific host tissue structures allows pathogenic bacteria to establish an infection and facilitates the spread within its host. Interactions between bacterial surface structures and human proteins might determine the outcome of the infection. Streptococcus pyogenes (S. LÄS MER