Sökning: "exogenous variation"

Visar resultat 1 - 5 av 66 avhandlingar innehållade orden exogenous variation.

  1. 1. Genomic Variation and Evolution of HERV-H and other Endogenous Retroviruses (ERVs)

    Författare :Patric Jern; Jonas Blomberg; Michael Tristem; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Microbiology; Endogenous Retrovirus ERV ; HERV-H; Phylogeny; Evolution; Sequence Variation; Polymorphism; Recent Integrations; Horizontal Transfer; Master Elements; Taxonomy; Mikrobiologi; Microbiology; immunology; infectious diseases; Mikrobiologi; immunologi; infektionssjukdomar;

    Sammanfattning : An exogenous retrovirus (XRV) that integrates into a germ cell may be inherited as a Mendelian gene; it becomes an endogenous retrovirus (ERV). The human genome consists of up to 8% HERVs. The gammaretroviral (ERV class I) HERV-H, with 926 members, is the largest ERV group. LÄS MER

  3. 2. Essays on Risk Attitudes in Sub-Saharan Africa

    Författare :Mohammad H. Sepahvand; Ranjula Bali; Chuan-Zhong Li; Supriya Garikipati; Uppsala universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Risk attitudes; determinants of risk taking; test-retest reliability; gender; inter and multigenerational transmission; socialization; family background; sibling correlations; exogenous shock; revolution; gender differences; agriculture; productivity; Burkina Faso; Economics; Nationalekonomi; Economics; Nationalekonomi;

    Sammanfattning : Essay I (submitted): Risk-taking is an important topic in Africa, as access to financial institutions and social security is scarce. Data on risk attitudes in Africa is limited and the available data collected might not be reliable. LÄS MER

  4. 3. Real-time breath gas analysis of carbon monoxide : laser-based detection and pulmonary gas exchange modeling

    Författare :Ramin Ghorbani; Florian M. Schmidt; Anders Blomberg; Christoffer Boman; Staffan Schedin; Jonathan Beauchamp; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; carbon monoxide CO ; pulmonary gas exchange; computational modeling; real-time breath gas analysis; single-exhalation profile; laser absorption spectroscopy; nonlinear least-squares fitting; breath sampling; baseline level; diurnal variation; healthy population; exposure study; fysik; Physics; Physiology; fysiologi;

    Sammanfattning : Breath gas analysis is a promising approach for non-invasive medical diagnostics and physiological monitoring. Real-time, breath-cycle resolved biomarker detection facilitates data interpretation and has the potential to improve the diagnostic value of breath tests as exhalation profiles carry spatiotemporal information about biomarker origin and gas exchange in the respiratory tract. LÄS MER

  5. 4. Expression of Genes Encoding for Drug Metabolism in the Small Intestine

    Författare :Monica Lindell; Hans Lennernäs; Matti Lang; Olavi Pelkonen; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biochemistry; CYPs; UGTs; interindividual variation; small intestine; human; rat; artemisinin; CAR-receptor regulation; Farmaceutisk biokemi; Pharmaceutical biochemistry; Farmaceutisk biokemi;

    Sammanfattning : This investigation focused on the mRNA expression of drug metabolising Cytochromes P-450 (CYP) and UDP-glucuronosyltransferases (UGT) and the transport protein P-glycoprotein (Pgp) in the small intestine of humans and rats.The mRNA expression of the investigated genes in the human small intestine (duodenum) varies between individuals giving each one of us personal profile. LÄS MER

  7. 5. Interindividual variation in drug metabolism with focus on polymorphic cytochrome P450 2C9

    Författare :Mia Sandberg Lundblad; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cytochromes P450 (CYP) are enzymes, mainly catalysing the oxidation of xenobiotics, in order to facilitate their excretion from the body. CYP2C9 is a polymorphic enzyme, which is responsible for the metabolism of about 10 % of all known drugs, e. LÄS MER