Sökning: "immunology"

Visar resultat 1 - 5 av 834 avhandlingar innehållade ordet immunology.

  1. 1. Dissecting the Microenvironment of Urothelial Bladder Cancer : Therapy, Modelling and Biomarkers

    Författare :Iliana Kyriaki Kerzeli; Sara Mangsbo; Tania de Gruijl; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immuno-oncology; Tumor immunology; MALT1 inhibition; Urothelial bladder cancer; Tumor microenvironment; Immunologi; Immunology; Oncology; Onkologi; Urologi; Urology;

    Sammanfattning : The complexity of the tumor microenvironment (TME) impacts therapy responses and the survival of cancer patients. The scope of this thesis is to study the effects of immune modulation on tumor-infiltrating leukocytes, and to explore the TME of urothelial cancer to provide the research society with new knowledge and potential therapeutic targets. LÄS MER

  3. 2. Glutamate and GABA signalling components in the human brain and in immune cells

    Författare :Amol K. Bhandage; Bryndis Birnir; Gerard P. Ahern; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Neuroscience; Neurovetenskap; Immunologi; Immunology;

    Sammanfattning : Glutamate and γ-aminobutyric acid (GABA) are the principal excitatory and inhibitory neurotransmitters in the central nervous system (CNS). They both can activate their ionotropic and metabotropic receptors. LÄS MER

  4. 3. Modulation of B cell access to antigen by passively administered antibodies : an explanation for antibody feedback regulation?

    Författare :Hui Xu; Birgitta Heyman; Helena Harris; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IgG; IgG3; IgE; suppression; enhancement; epitope masking; antigen transport; antigen presentation; follicular B cells; marginal zone B cells; Immunologi; Immunology;

    Sammanfattning : Antibody responses can be up- or down-regulated by passive administration of specific antibody together with antigen. Depending on the structure of the antigen and the antibody isotype, responses can be completely suppressed or enhanced up to a 1000-fold of what is seen in animals immunized with antigen alone. LÄS MER

  5. 4. Immune complex induced IgG1-rheumatoid factor production

    Författare :Eva Nordström; Jan Andersson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; immunologi; Immunology;

    Sammanfattning : Rheumatoid arthritis is a chronic crippling disease mainly characterised by inflammation in the joints. Most patients with rheumatoid arthritis are seropositive, i.e. have increased serum levels of antibodies against the constant part of IgG, so called rheumatoid factors (RF). LÄS MER

  7. 5. Immunological and functional properties of a non-repeat region in Plasmodium falciparum antigen Pf155/RESA

    Författare :Siddique Abu Bakar; Lars Hvid; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; immunologi; Immunology;

    Sammanfattning : Plasmodium falciparum malaria is one of the most prevalent of all the great insect-borne diseases causing high morbidity and mortality in humans. As conventional anti-malarial treatment is becoming increasingly inefficient, alternative approaches to combat the parasite, like vaccine development, are of high priority. LÄS MER