Sökning: "enzymatic regulation"

Visar resultat 21 - 25 av 107 avhandlingar innehållade orden enzymatic regulation.

  1. 21. Regulation and function of thioredoxin reductase 1 in human tumor cells

    Författare :Markus Selenius; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The thioredoxin system is a general protein disulfide reductase system present in all organisms. Its function is to maintain an intracellular reducing environment and upholding a defense against reactive oxygen species generated as by-products of aerobic metabolism. LÄS MER

  3. 22. Oxidation of Ketones: A (Chemo-) Enzymatic Approach Using Oxygenases and Hydrolases

    Författare :Georgina Chávez; Bioteknik; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; cross linked enzyme aggregates.; caprolactone; perhydrolase; Lipase B from Candida antarctica;

    Sammanfattning : Oxidation reactions are important in organic chemistry as well as in nature. In industry, oxidations are commonly used for the synthesis of chemicals and pharmaceuticals, however such processes have a number of limitations, they use chlorinated solvents, stoichiometric oxidation reagents, and in some cases the reagents that have risks of explosion during transportation and storage. LÄS MER

  4. 23. Nucleoside analoge cytotoxicity-focus on enzyme regulation, metabolism, and mechanisms of resistance

    Författare :Anna Fyrberg; Kourosh Lotfi; Curt Peterson; Freidoun Albertioni; Francoise Bontemps; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; Farmakologi;

    Sammanfattning : The aim of this thesis was to determine the role of nucleoside analog activating and deactivating enzymes in nucleoside analog metabolism and resistance development. Nucleoside analogs are anti-cancer drogs and are often used to treat different leukemias, attributably to presence of high levels of nucleoside analog activating enzymes in hematopoietic cells. LÄS MER

  5. 24. Regulation of tartrate-resistant purple acid phosphatase by proteolytic processing in rat

    Författare :Jenny Ljusberg-Sjölander; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Purple acid phosphatase; enzyme catalysis; proteolytic processing;

    Sammanfattning : Purple acid phosphatase (PAP) is an iron-containing binuclear acid metallohydrolase with a characteristic purple colour, also referred to as tartrate-resistant acid phosphatase (TRAP), uteroferrin or type 5 acid phosphatase. PAP is highly expressed in osteoclasts and has a role in bone resorption. LÄS MER

  7. 25. Regulation of human thioredoxin and glutaredoxin systems by oxidation and S-nitrosylation

    Författare :Seyed Isaac Hashemy; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The homeostasis of intracellular redox status has a crucial role in the cell survival and different processes such as DNA synthesis, gene expression, enzymatic activity, etc. This homeostasis is achieved via an intense balance between pro-oxidants and anti-oxidants. LÄS MER