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Visar resultat 6 - 10 av 13 avhandlingar som matchar ovanstående sökkriterier.

  1. 6. Vascular smooth muscle mechanotransduction and plasticity-the role of microRNA, calcium signaling and actin polymerization

    Författare :Karolina Turczynska; Kärlfysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PYK2; actin polymerization; calcium; microRNA; stretch;

    Sammanfattning : Smooth muscle cells residing in the blood vessel media are constantly exposed to mechanical forces exerted by the intraluminal pressure. The smooth muscle senses and adapts to mechanical forces by activation of multiple signaling pathways and cytoskeletal rearrangements. LÄS MER

  3. 7. Functional role of cytoskeletal, contractile and regulatory proteins in muscle disease

    Författare :Mei Li; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The function of skeletal muscle is an essential component of animal physiology and daily life. Hereditary muscle diseases are comparatively rare in humans, but often very severe. The disease causes are heterogeneous, defects in nerves, intracellular components, structural proteins and the contractile apparatus can be involved. LÄS MER

  4. 8. Alpha-actinin - an amazing journey through time and species

    Författare :Barbara Addario; Lars Backman; Yari Ylänne; Umeå universitet; []
    Nyckelord :;

    Sammanfattning : In eukaryotes, the actin cytoskeleton plays an important role in a large variety of cellular events. Its reorganization is regulated by a plethora of actin-modulating proteins, such as α-actinin. α-actinin is a ubiquitous actin-binding protein that belongs to the spectrin superfamily. LÄS MER

  5. 9. Molecular characterization and evolution of alpha-actinin : from protozoa to vertebrates

    Författare :Ana Virel; Lars Backman; Kristina Djinovic-Carugo; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; alpha-actinin; evolution; spectrin repeat; intragene duplication; phylogenetic tree; spectrin superfamily; Biochemistry; Biokemi;

    Sammanfattning : alpha-actinin is a ubiquitous protein found in most eukaryotic organisms. The ability to form dimers allows alpha-actinin to cross-link actin in different structures. In muscle cells alpha-actinin is found at the Z-disk of sarcomeres. LÄS MER

  7. 10. Extraocular Muscles in Amyotrophic Lateral Sclerosis

    Författare :Anton Tjust; Fatima Pedrosa Domellöf; Mona Lindström; Thomas Brännström; Eva Hedlund; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ALS; EOM; Satellite cells; innervation; neuromuscular disease; neurodegenerative disease; anatomi; Human Anatomy;

    Sammanfattning : Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease of motor neurons characterized by muscle paralysis and death within 3-5 years of onset. However, due to unknown mechanisms, the extraocular muscles (EOMs) remain remarkably unaffected. LÄS MER