Sökning: "dry granulation"

Hittade 4 avhandlingar innehållade orden dry granulation.

  1. 1. Tableting performance of dry granulated particles : Significance and assessment of compression mechanical properties

    Författare :Maryam Tofiq; Göran Alderborn; Ann-Sofie Persson; Josefina Nordström; Peter Kleinebudde; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dry granulation; Powder compression; Compression parameters; Granule composition; Granule structure; Granule strength; Granule fragmentation; Granule deformation; Tablet tensile strength; Loss of tabletability;

    Sammanfattning : Dry granulation (DG) is often utilized as an intermediate process during tablet manufacturing, for improving flow characteristics of the powder blend and/or reducing segregation issues related to the active pharmaceutical ingredient (API). The resulting granules exhibit typically irregular shapes with rough surfaces and their mechanical properties are related to the feeding powder and the process parameters used during the DG. LÄS MER

  3. 2. Multivariate Synergies in Pharmaceutical Roll Compaction : The quality influence of raw materials and process parameters by design of experiments

    Författare :Nabil Souihi; Johan Trygg; Jukka Rantanen; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Roll compaction; dry granulation; mannitol; dicalcium phosphate; design of experiments; orthogonal projections to latent structures; critical quality attributes; tablet manufacturing; quality by design; design space; near-infrared chemical imaging; texture analysis; modeling; scale up; instrumented roll; Johanson model;

    Sammanfattning : Roll compaction is a continuous process commonly used in the pharmaceutical industry for dry granulation of moisture and heat sensitive powder blends. It is intended to increase bulk density and improve flowability. LÄS MER

  4. 3. Rheological modeling of particle flows in high shear granulation

    Författare :Mohammad Khalilitehrani; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; continuum modeling; rheology; disc impeller; high shear granulation;

    Sammanfattning : High shear granulation is an important process in a wide variety of applications, more specifically in pharmaceutical industries as a basic step in the tableting process. The process includes two major steps: dry high shear granulation and wet high shear granulation. It aims at producing granules with a specific size and material composition. LÄS MER

  5. 4. Ash Products for Nutrient Recycling in Forestry : Leaching and Drying Characteristics

    Författare :Peter Mellbo; Tommy Claesson; Sirkku Sarenbo; Hans Samuelsson; Högskolan i Kalmar; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Ash products; Wood ash; Leaching; Drying; Nutrient; ; Sustainable forestry; Forestry; Skogsskötsel; Miljövetenskap; Environmental Science;

    Sammanfattning : As the demand for carbon dioxide neutral energy sources increases, forestry becomes more intensive. Entire trees are removed from the felling sites threatening the nutrient balance of the forest soils. LÄS MER