Sökning: "dorsal raphe nucleus"

Visar resultat 6 - 10 av 14 avhandlingar innehållade orden dorsal raphe nucleus.

  1. 6. Leptin targets in the brain regulating body weight : receptors and down-stream mediators of leptin in neurons of the hypothalamus and brainstem

    Författare :Marie-Louise Håkansson Ovesjö; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :AGRP; antibody; arcuate nucleus; blood-brain-barrier; body weight; brainstem; CART; CRH; DMX; food intake; GABA; GAD; galanin; hypothalamus; immunohistochemistry; in situ hybridization; lateral hypothalamic area; leptin; leptin receptor; MCH; NPY; obesity; Ob-R; Ob-Rb; oxytocin; paraventricular nucleus; POMC; somatostatin; serotonin; STAT3; supraoptic nucleus; transcription factor; vasopressin; VGAT;

    Sammanfattning : Obesity is a disease which has become a global epidemic that is beginning to replace undernutrition and infectious diseases as the most significant contributor to ill health in the world. In particular, obesity is associated with diabetes mellitus, hypertension and coronary heart disease. LÄS MER

  3. 7. Interactions between the brain and the immune system in pain and inflammation

    Författare :Joanna Zajdel; David Engblom; Annika Thorsell; Jan Pieter Konsman; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; inflammation; pain; EP3Rs; serotonin; CGRP; conditioned taste aversion; maternal separation; maternal buffering;

    Sammanfattning : Reciprocal interactions between the nervous and immune systems have gained a lot of attention in the last two decades, especially after demonstrating that cytokine immunotherapies can induce depression and after describing the inflammatory reflex. A lot of effort has been dedicated to understanding how the signals from the immune system reach the brain and vice versa, and on their role in health and disease. LÄS MER

  4. 8. PET studies of the serotonin system in major depression and its treatment

    Författare :Mikael Tiger; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The serotonin system has been implicated in major depression since the 1960s, mainly based on the serotonin enhancing properties of antidepressants. Positron emission tomography, PET, is the in vivo molecular imaging method with the best spatial resolution. LÄS MER

  5. 9. Noradrenergic augmentation strategies in the pharmacological treatment of depression and schizophrenia : an experimental study

    Författare :Love Linnér; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The pharmacological treatment of depression and schizophrenia, two major psychiatric disorders, is largely based on modulation of central monoaminergic neurotransmission. However, currently available pharmacological treatment alternatives possess a relatively modest clinical efficacy, making them less than optimal. LÄS MER

  7. 10. Molecular and functional neuroanatomy of mood disorder circuits

    Författare :Antje Märtin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The ability to interpret and react to external stimuli is essential for survival. An organism has to be able to predict a favorable outcome, and, more importantly, a non-favorable one that could mean danger for life. LÄS MER