Sökning: "deep mutational scanning"

Hittade 2 avhandlingar innehållade orden deep mutational scanning.

1. 1. Diving into short linear motifs : Large-scale identification of endogenous and host-pathogen protein-protein interactions and further characterized by deep mutational scanning

   Författare :Caroline Benz; Ylva Ivarsson; Birthe B. Kragelund; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein-protein interactions; short linear motif; endogenous interactions; host-pathogen; viral hijacking; deep mutational scanning; Biokemi; Biochemistry;

   Sammanfattning : Short linear motifs (SLiMs) are protein-protein interaction sites that play an essential role in distinct cellular processes. Those interactions are challenging to capture by common high-throughput methods. LÄS MER

3. 2. Immunoglobulin gene usage and affinity maturation in antiviral antibodies

   Författare :Pradeepa Pushparaj; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The ability of antibodies to block infections makes them highly relevant for successful vaccine development. Through the papers described in this thesis, I attempt to characterize the functional and genetic aspects of antiviral antibodies induced by infection and vaccination. LÄS MER